ITGAV [The Human Chemical-Genetic Interaction Map Project]

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======= ITGAV =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGAV
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha V
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3685|3685]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06756|P06756]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGAV&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGAV|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/193210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). {ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:17158881, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877}. (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1. {ECO:0000269|PubMed:15194773, ECO:0000269|PubMed:7519807, ECO:0000269|PubMed:9426447}. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1. {ECO:0000269|PubMed:24367260}. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus. {ECO:0000269|PubMed:23658209}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|opsonin binding|
|modulation of phagocytosis in other organism involved in symbiotic interaction|
|positive regulation by organism of phagocytosis in other organism involved in symbiotic interaction|
|positive regulation by symbiont of host phagocytosis|
|modulation by symbiont of host phagocytosis|
|entry of symbiont into host cell by promotion of host phagocytosis|
|integrin alphav-beta3 complex|
|integrin alphav-beta5 complex|
|negative regulation of entry of bacterium into host cell|
|integrin alphav-beta8 complex|
|transforming growth factor-beta secretion|
|integrin alphav-beta6 complex|
|alphav-beta3 integrin-HMGB1 complex|
|alphav-beta3 integrin-PKCalpha complex|
|negative regulation of low-density lipoprotein particle receptor biosynthetic process|
|negative regulation of lipoprotein metabolic process|
|alphav-beta3 integrin-IGF-1-IGF1R complex|
|C-X3-C chemokine binding|
|neuregulin binding|
|apolipoprotein A-I-mediated signaling pathway|
|extracellular matrix protein binding|
|negative regulation of receptor biosynthetic process|
|regulation of entry of bacterium into host cell|
|regulation of transforming growth factor beta activation|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|positive regulation of osteoblast proliferation|
|insulin-like growth factor I binding|
|regulation of lipoprotein metabolic process|
|negative regulation of macrophage derived foam cell differentiation|
|filopodium membrane|
|negative regulation of lipid storage|
|lamellipodium membrane|
|regulation of osteoblast proliferation|
|transforming growth factor beta binding|
|cell adhesion mediated by integrin|
|regulation of receptor biosynthetic process|
|fibroblast growth factor binding|
|microvillus membrane|
|integrin complex|
|modulation by symbiont of host cellular process|
|negative regulation of lipid transport|
|fibronectin binding|
|extracellular matrix binding|
|ERK1 and ERK2 cascade|
|regulation of macrophage derived foam cell differentiation|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|coreceptor activity|
|regulation of transforming growth factor beta production|
|heterotypic cell-cell adhesion|
|apoptotic cell clearance|
|voltage-gated calcium channel activity|
|negative regulation of lipid localization|
|endodermal cell differentiation|
|modification by symbiont of host morphology or physiology|
|regulation of lipid storage|
|negative chemotaxis|
|endoderm formation|
|cytokine secretion|
|substrate adhesion-dependent cell spreading|
|protein kinase C binding|
|phagocytic vesicle|
|vascular endothelial growth factor receptor signaling pathway|
|vasculogenesis|
|positive regulation of phagocytosis|
|endoderm development|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|virus receptor activity|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|specific granule membrane|
|integrin-mediated signaling pathway|
|viral entry into host cell|
|regulation of phagocytosis|
|ruffle membrane|
|extrinsic apoptotic signaling pathway|
|antigen processing and presentation of peptide antigen via MHC class I|
|negative regulation of extrinsic apoptotic signaling pathway|
|entry into host|
|protease binding|
|entry into host cell|
|regulation of lipid transport|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|formation of primary germ layer|
|cell-matrix adhesion|
|integrin binding|
|regulation of lipid localization|
|cytokine production|
|regulation of extrinsic apoptotic signaling pathway|
|modification of morphology or physiology of other organism|
|interaction with host|
|protein secretion|
|gastrulation|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|cell-substrate adhesion|
|antigen processing and presentation of peptide antigen|
|calcium ion transmembrane transport|
|viral life cycle|
|negative regulation of multi-organism process|
|antigen processing and presentation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|negative regulation of apoptotic signaling pathway|
|calcium ion transport|
|positive regulation of cytosolic calcium ion concentration|
|apoptotic signaling pathway|
|divalent metal ion transport|
|divalent inorganic cation transport|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|phagocytosis|
|extracellular matrix organization|
|MAPK cascade|
|leukocyte migration|
|extracellular structure organization|
|signal transduction by protein phosphorylation|
|external side of plasma membrane|
|regulation of apoptotic signaling pathway|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|focal adhesion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|negative regulation of transport|
|blood vessel development|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|leukocyte degranulation|
|cardiovascular system development|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|embryonic morphogenesis|
|myeloid leukocyte activation|
|cation transmembrane transport|
|cell surface|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|tube morphogenesis|
|regulation of cell adhesion|
|regulation of cytokine production|
|viral process|
|regulated exocytosis|
|cation homeostasis|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|ion homeostasis|
|exocytosis|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|cation transport|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|ion transmembrane transport|
|cell migration|
|protein phosphorylation|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|export from cell|
|programmed cell death|
|cell activation|
|localization of cell|
|cell motility|
|cell death|
|immune effector process|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|secretion|
|negative regulation of signal transduction|
|transmembrane transport|
|phosphorylation|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|ion transport|
|integral component of plasma membrane|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 144/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|6/28|
|blood|0/28|
|bone|2/26|
|breast|8/33|
|central nervous system|20/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|11/21|
|liver|9/20|
|lung|21/75|
|lymphocyte|0/16|
|ovary|4/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|6/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14257
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGAV Expression in NALM6 Cells: 4.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>