ITGAX [The Human Chemical-Genetic Interaction Map Project]

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======= ITGAX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGAX
  * **<color #00a2e8>Official Name</color>**: integrin subunit alpha X
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3687|3687]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20702|P20702]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGAX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGAX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151510|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin alpha2|
|VWA|
|FG-GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of endothelial tube morphogenesis|
|regulation of endothelial tube morphogenesis|
|positive regulation of myelination|
|integrin complex|
|positive regulation of morphogenesis of an epithelium|
|heterotypic cell-cell adhesion|
|regulation of myelination|
|receptor tyrosine kinase binding|
|ficolin-1-rich granule membrane|
|positive regulation of nervous system process|
|tertiary granule membrane|
|integrin-mediated signaling pathway|
|secretory granule membrane|
|regulation of nervous system process|
|positive regulation of angiogenesis|
|regulation of morphogenesis of an epithelium|
|positive regulation of vasculature development|
|signaling receptor activity|
|regulation of angiogenesis|
|regulation of vasculature development|
|extracellular matrix organization|
|leukocyte migration|
|extracellular structure organization|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|cell-cell adhesion|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|myeloid leukocyte activation|
|regulation of system process|
|protein-containing complex|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cytokine-mediated signaling pathway|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|response to cytokine|
|secretion|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|regulation of cell population proliferation|
|positive regulation of multicellular organismal process|
|immune response|
|vesicle-mediated transport|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.75|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.7|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.76|
|[[:results:exp124|GSK343 3μM R03 exp124]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:napa|NAPA]]|0.437|
|[[:human genes:t:tyms|TYMS]]|0.419|
|[[:human genes:p:psmb2|PSMB2]]|0.417|
|[[:human genes:a:aqr|AQR]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2218
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGAX Expression in NALM6 Cells: 2.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>