ITGB3 [The Human Chemical-Genetic Interaction Map Project]

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======= ITGB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITGB3
  * **<color #00a2e8>Official Name</color>**: integrin subunit beta 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3690|3690]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05106|P05106]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITGB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITGB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/173470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Integrin alpha-V/beta-3 (ITGAV:ITGB3) is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha- IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. Fibrinogen binding enhances SELP expression in activated platelets (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and acts as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324). ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119). ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGAV:ITGB3 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887). {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:12807887, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:24789099, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:9195946, ECO:0000303|PubMed:16322781, ECO:0000303|PubMed:17635696}. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Coxsackievirus A9. {ECO:0000269|PubMed:7519807}. (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Cytomegalovirus/HHV-5. {ECO:0000269|PubMed:15834425}. (Microbial infection) Integrin ITGAV:ITGB3 acts aP05556s a receptor for Human parechovirus 1. {ECO:0000269|PubMed:11160695}. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. {ECO:0000269|PubMed:10397733}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Integrin b cyt|
|Integrin beta|
|Integrin B tail|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin alphav-beta3 complex|
|alphav-beta3 integrin-vitronectin complex|
|negative regulation of low-density lipoprotein particle receptor biosynthetic process|
|alphav-beta3 integrin-HMGB1 complex|
|alphav-beta3 integrin-PKCalpha complex|
|alphav-beta3 integrin-IGF-1-IGF1R complex|
|negative regulation of lipoprotein metabolic process|
|regulation of serotonin uptake|
|C-X3-C chemokine binding|
|fibrinogen binding|
|apolipoprotein A-I-mediated signaling pathway|
|neuregulin binding|
|negative regulation of receptor biosynthetic process|
|vascular endothelial growth factor receptor 2 binding|
|regulation of low-density lipoprotein particle receptor biosynthetic process|
|smooth muscle cell migration|
|regulation of postsynaptic neurotransmitter receptor internalization|
|insulin-like growth factor I binding|
|regulation of lipoprotein metabolic process|
|negative regulation of macrophage derived foam cell differentiation|
|angiogenesis involved in wound healing|
|positive regulation of vascular endothelial growth factor receptor signaling pathway|
|platelet-derived growth factor receptor binding|
|platelet alpha granule membrane|
|protein disulfide isomerase activity|
|filopodium membrane|
|negative regulation of lipid storage|
|regulation of neurotransmitter uptake|
|lamellipodium membrane|
|muscle cell migration|
|fibroblast growth factor binding|
|regulation of receptor biosynthetic process|
|cell adhesion mediated by integrin|
|microvillus membrane|
|integrin complex|
|negative regulation of lipid transport|
|mesodermal cell differentiation|
|fibronectin binding|
|extracellular matrix binding|
|regulation of macrophage derived foam cell differentiation|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|coreceptor activity|
|heterotypic cell-cell adhesion|
|apoptotic cell clearance|
|regulation of bone resorption|
|negative regulation of lipid localization|
|platelet aggregation|
|negative chemotaxis|
|regulation of lipid storage|
|regulation of bone remodeling|
|substrate adhesion-dependent cell spreading|
|regulation of receptor internalization|
|cell adhesion molecule binding|
|homotypic cell-cell adhesion|
|vascular endothelial growth factor receptor signaling pathway|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of tissue remodeling|
|virus receptor activity|
|integrin-mediated signaling pathway|
|positive regulation of endothelial cell proliferation|
|viral entry into host cell|
|ruffle membrane|
|positive regulation of endothelial cell migration|
|regulation of receptor-mediated endocytosis|
|melanosome|
|entry into host|
|entry into host cell|
|protease binding|
|regulation of lipid transport|
|formation of primary germ layer|
|mesoderm development|
|cell-matrix adhesion|
|platelet degranulation|
|regulation of endothelial cell proliferation|
|integrin binding|
|regulation of lipid localization|
|platelet activation|
|positive regulation of epithelial cell migration|
|regulation of neurotransmitter transport|
|interaction with host|
|regulation of endothelial cell migration|
|gastrulation|
|cell-substrate adhesion|
|positive regulation of epithelial cell proliferation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|viral life cycle|
|receptor complex|
|regulation of endocytosis|
|regulation of epithelial cell migration|
|regulation of peptidyl-tyrosine phosphorylation|
|synapse|
|regulation of cellular response to growth factor stimulus|
|blood coagulation|
|coagulation|
|hemostasis|
|angiogenesis|
|activation of protein kinase activity|
|phagocytosis|
|regulation of epithelial cell proliferation|
|extracellular matrix organization|
|enzyme binding|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|leukocyte migration|
|extracellular structure organization|
|blood vessel morphogenesis|
|focal adhesion|
|wound healing|
|negative regulation of transport|
|blood vessel development|
|regulation of body fluid levels|
|positive regulation of cell migration|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|response to wounding|
|positive regulation of kinase activity|
|cell surface|
|tube morphogenesis|
|positive regulation of transferase activity|
|regulation of ion transport|
|viral process|
|regulated exocytosis|
|regulation of protein transport|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|symbiotic process|
|exocytosis|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|regulation of transferase activity|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|secretion by cell|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|identical protein binding|
|cell activation|
|cell motility|
|localization of cell|
|negative regulation of protein metabolic process|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|locomotion|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|cell development|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITGB3 Expression in NALM6 Cells: 0.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>