ITPK1 [The Human Chemical-Genetic Interaction Map Project]

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======= ITPK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITPK1
  * **<color #00a2e8>Official Name</color>**: inositol-tetrakisphosphate 1-kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3705|3705]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13572|Q13572]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITPK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITPK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601838|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ins134 P3 kin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol-1,3,4-trisphosphate 6-kinase activity|
|inositol-1,3,4-trisphosphate 5-kinase activity|
|inositol tetrakisphosphate 1-kinase activity|
|inositol tetrakisphosphate 6-kinase activity|
|inositol phosphorylation|
|inositol metabolic process|
|isomerase activity|
|inositol trisphosphate metabolic process|
|necroptotic process|
|carbohydrate phosphorylation|
|programmed necrotic cell death|
|necrotic cell death|
|catalytic activity|
|inositol phosphate metabolic process|
|hydrolase activity|
|polyol metabolic process|
|neural tube development|
|cellular carbohydrate metabolic process|
|magnesium ion binding|
|blood coagulation|
|coagulation|
|hemostasis|
|alcohol metabolic process|
|apical plasma membrane|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|wound healing|
|regulation of body fluid levels|
|response to wounding|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube development|
|organophosphate metabolic process|
|embryo development|
|programmed cell death|
|cell death|
|epithelium development|
|phosphorylation|
|ATP binding|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.86|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.58|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.57|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.55|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.35|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.33|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.31|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.3|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.2|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.17|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.06|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.01|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.01|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.87|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.85|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.79|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.71|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.76|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.77|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.78|
|[[:results:exp183|IU1-C 25μM R04 exp183]]|1.78|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.79|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.79|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.79|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.8|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.83|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.9|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|1.92|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.95|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.96|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|1.97|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.97|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.98|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.01|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.04|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|2.06|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.09|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.09|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|2.12|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.18|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.24|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.29|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.31|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|2.32|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.36|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|2.39|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.39|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.79|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.8|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.92|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|3.17|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|3.31|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|3.31|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|3.7|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|4.1|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|4.22|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|5.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ipmk|IPMK]]|0.7|
|[[:human genes:i:ippk|IPPK]]|0.514|
|[[:human genes:a:anp32a|ANP32A]]|0.508|
|[[:human genes:p:pds5b|PDS5B]]|0.468|
|[[:human genes:s:sap130|SAP130]]|0.468|
|[[:human genes:a:arid4b|ARID4B]]|0.447|
|[[:human genes:m:mettl14|METTL14]]|0.436|
|[[:human genes:c:c7orf26|C7orf26]]|0.422|
|[[:human genes:r:rbm26|RBM26]]|0.417|
|[[:human genes:z:zbtb18|ZBTB18]]|0.413|
|[[:human genes:u:ube4b|UBE4B]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10279
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITPK1 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>