ITPR2 [The Human Chemical-Genetic Interaction Map Project]

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======= ITPR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: ITPR2
  * **<color #00a2e8>Official Name</color>**: inositol 1,4,5-trisphosphate receptor type 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3709|3709]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14571|Q14571]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=ITPR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20ITPR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA (By similarity). {ECO:0000250|UniProtKB:Q9Z329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIH assoc|
|RYDR ITPR|
|MIR|
|Ion trans|
|Ins145 P3 rec|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|
|calcium ion transmembrane transporter activity|
|platelet dense tubular network membrane|
|inositol 1,4,5 trisphosphate binding|
|cellular response to ethanol|
|inositol phosphate-mediated signaling|
|sarcoplasmic reticulum membrane|
|sarcoplasmic reticulum|
|cellular response to cAMP|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|scaffold protein binding|
|calcium ion transmembrane import into cytosol|
|regulation of cardiac conduction|
|calcium ion transport into cytosol|
|cellular response to alcohol|
|phosphatidylinositol binding|
|cytosolic calcium ion transport|
|secretory granule membrane|
|response to cAMP|
|cellular response to antibiotic|
|regulation of sequestering of calcium ion|
|response to ethanol|
|response to organophosphorus|
|cell cortex|
|platelet activation|
|cytoplasmic vesicle membrane|
|response to purine-containing compound|
|regulation of insulin secretion|
|calcium ion transmembrane transport|
|receptor complex|
|regulation of peptide hormone secretion|
|cellular response to toxic substance|
|response to alcohol|
|regulation of heart contraction|
|calcium ion transport|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|blood coagulation|
|coagulation|
|divalent metal ion transport|
|hemostasis|
|divalent inorganic cation transport|
|response to antibiotic|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|cellular response to drug|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|regulation of body fluid levels|
|response to toxic substance|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|response to wounding|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|calcium ion binding|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|cell activation|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|intracellular signal transduction|
|establishment of localization in cell|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.93|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-1.74|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.73|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12488
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='ITPR2 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>