IWS1 [The Human Chemical-Genetic Interaction Map Project]

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======= IWS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: IWS1
  * **<color #00a2e8>Official Name</color>**: interacts with SUPT6H, CTD assembly factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55677|55677]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96ST2|Q96ST2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=IWS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20IWS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. {ECO:0000269|PubMed:17184735, ECO:0000269|PubMed:17234882, ECO:0000269|PubMed:19141475}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Med26|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of histone H3-K36 trimethylation|
|regulation of mRNA export from nucleus|
|regulation of histone H3-K36 methylation|
|regulation of ribonucleoprotein complex localization|
|regulation of histone H4 acetylation|
|regulation of RNA export from nucleus|
|regulation of nucleobase-containing compound transport|
|regulation of protein export from nucleus|
|regulation of histone acetylation|
|regulation of peptidyl-lysine acetylation|
|regulation of histone methylation|
|regulation of protein acetylation|
|transcription elongation from RNA polymerase II promoter|
|DNA-templated transcription, elongation|
|regulation of nucleocytoplasmic transport|
|regulation of mRNA processing|
|regulation of histone modification|
|mRNA transport|
|regulation of chromatin organization|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|regulation of intracellular protein transport|
|nucleobase-containing compound transport|
|regulation of mRNA metabolic process|
|regulation of chromosome organization|
|regulation of intracellular transport|
|RNA splicing|
|mRNA processing|
|transcription by RNA polymerase II|
|regulation of cellular protein localization|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|RNA processing|
|regulation of cellular localization|
|regulation of protein localization|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of organelle organization|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.36|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-2.32|
|[[:results:exp331|A-769662 20μM R07 exp331]]|-2.21|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.94|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.89|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.84|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-1.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.79|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.72|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.7|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.71|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|1.72|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.73|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.74|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.74|
|[[:results:exp218|A-395 10μM R05 exp218]]|1.78|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.82|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='IWS1 Expression in NALM6 Cells: 6.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>