KANSL3 [The Human Chemical-Genetic Interaction Map Project]

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======= KANSL3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KANSL3
  * **<color #00a2e8>Official Name</color>**: KAT8 regulatory NSL complex subunit 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55683|55683]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P2N6|Q9P2N6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KANSL3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KANSL3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Abhydrolase 5|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NSL complex|
|histone acetyltransferase activity (H4-K8 specific)|
|histone acetyltransferase activity (H4-K5 specific)|
|histone acetyltransferase activity (H4-K16 specific)|
|histone H4-K5 acetylation|
|histone H4-K8 acetylation|
|histone H4-K16 acetylation|
|histone acetyltransferase complex|
|histone H4 acetylation|
|histone acetylation|
|internal peptidyl-lysine acetylation|
|peptidyl-lysine acetylation|
|internal protein amino acid acetylation|
|protein acetylation|
|protein acylation|
|peptidyl-lysine modification|
|histone modification|
|covalent chromatin modification|
|intracellular membrane-bounded organelle|
|chromatin organization|
|nucleolus|
|peptidyl-amino acid modification|
|chromosome organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.73|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.73|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.8|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.85|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.08|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:kansl1|KANSL1]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 601/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|24/28|
|bone|20/25|
|breast|31/33|
|central nervous system|45/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|14/15|
|kidney|14/21|
|liver|16/20|
|lung|62/75|
|lymphocyte|11/14|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|14/16|
|plasma cell|11/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|5/7|
|thyroid|0/2|
|upper aerodigestive|20/22|
|urinary tract|21/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 487
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KANSL3 Expression in NALM6 Cells: 6.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>