KATNB1 [The Human Chemical-Genetic Interaction Map Project]

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======= KATNB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KATNB1
  * **<color #00a2e8>Official Name</color>**: katanin regulatory subunit B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10300|10300]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BVA0|Q9BVA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KATNB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KATNB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602703|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:10751153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|WD40|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|katanin complex|
|mitotic chromosome movement towards spindle pole|
|positive regulation of microtubule depolymerization|
|chromosome movement towards spindle pole|
|microtubule-severing ATPase activity|
|microtubule severing|
|microtubule depolymerization|
|positive regulation of protein depolymerization|
|dynein complex binding|
|negative regulation of microtubule depolymerization|
|regulation of microtubule depolymerization|
|positive regulation of microtubule polymerization or depolymerization|
|protein depolymerization|
|positive regulation of protein complex disassembly|
|negative regulation of microtubule polymerization or depolymerization|
|microtubule polymerization or depolymerization|
|negative regulation of protein depolymerization|
|negative regulation of protein complex disassembly|
|establishment of chromosome localization|
|chromosome localization|
|regulation of microtubule polymerization or depolymerization|
|regulation of protein depolymerization|
|mitotic sister chromatid segregation|
|regulation of protein complex disassembly|
|spindle|
|spindle pole|
|growth cone|
|negative regulation of supramolecular fiber organization|
|cellular protein complex disassembly|
|negative regulation of cytoskeleton organization|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule cytoskeleton|
|midbody|
|regulation of microtubule cytoskeleton organization|
|positive regulation of supramolecular fiber organization|
|nuclear chromosome segregation|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|microtubule binding|
|protein-containing complex disassembly|
|microtubule-based movement|
|chromosome segregation|
|positive regulation of neuron projection development|
|nuclear division|
|organelle fission|
|microtubule|
|regulation of supramolecular fiber organization|
|protein targeting|
|establishment of organelle localization|
|positive regulation of neuron differentiation|
|neuronal cell body|
|negative regulation of organelle organization|
|positive regulation of cell projection organization|
|cellular component disassembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|microtubule cytoskeleton organization|
|protein heterodimerization activity|
|centrosome|
|cell division|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|organelle localization|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of neuron differentiation|
|microtubule-based process|
|mitotic cell cycle|
|regulation of plasma membrane bounded cell projection organization|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|intracellular protein transport|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|protein transport|
|intracellular transport|
|generation of neurons|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-3.66|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.19|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.98|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.26|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.73|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.73|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.17|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katna1|KATNA1]]|0.572|
|[[:human genes:w:wdr62|WDR62]]|0.453|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 66/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|3/28|
|bone|3/26|
|breast|5/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|2/21|
|liver|2/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|7/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2108
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KATNB1 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>