KCMF1 [The Human Chemical-Genetic Interaction Map Project]

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======= KCMF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCMF1
  * **<color #00a2e8>Official Name</color>**: potassium channel modulatory factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56888|56888]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P0J7|Q9P0J7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCMF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCMF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614719|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination. {ECO:0000269|PubMed:15581609}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ZZ|
|Di19|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ficolin-1-rich granule lumen|
|nucleic acid binding|
|ubiquitin protein ligase activity|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|protein ubiquitination|
|regulated exocytosis|
|leukocyte mediated immunity|
|protein modification by small protein conjugation|
|exocytosis|
|zinc ion binding|
|leukocyte activation|
|protein modification by small protein conjugation or removal|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|secretion|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.77|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.35|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-2.33|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.23|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.22|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.03|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-2.01|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.97|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.96|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.9|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.86|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.83|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.8|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-1.78|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.76|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.74|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.72|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.7|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.91|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|1.96|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.28|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.56|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.05|
|[[:results:exp539|42°C R08 exp539]]|3.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ubr4|UBR4]]|0.517|
|[[:human genes:r:rnf126|RNF126]]|0.502|
|[[:human genes:v:vcpip1|VCPIP1]]|0.476|
|[[:human genes:t:tmed10|TMED10]]|0.458|
|[[:human genes:o:otud5|OTUD5]]|0.454|
|[[:human genes:d:dnajc3|DNAJC3]]|0.452|
|[[:human genes:p:polr3h|POLR3H]]|0.442|
|[[:human genes:h:hmgb2|HMGB2]]|0.441|
|[[:human genes:x:xpo6|XPO6]]|0.425|
|[[:human genes:a:alg5|ALG5]]|0.422|
|[[:human genes:x:xpot|XPOT]]|0.416|
|[[:human genes:u:ubr5|UBR5]]|0.412|
|[[:human genes:u:usp34|USP34]]|0.406|
|[[:human genes:u:ube2j1|UBE2J1]]|0.406|
|[[:human genes:p:pnpla8|PNPLA8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 278/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|8/28|
|bone|4/26|
|breast|18/33|
|central nervous system|22/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|5/21|
|liver|7/20|
|lung|34/75|
|lymphocyte|6/16|
|ovary|6/26|
|pancreas|11/24|
|peripheral nervous system|2/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|11/24|
|soft tissue|6/9|
|thyroid|1/2|
|upper aerodigestive|13/22|
|urinary tract|10/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3152
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCMF1 Expression in NALM6 Cells: 5.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>