KCNA5 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNA5
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily A member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3741|3741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22460|P22460]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176267|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7). [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed:12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed:8505626, PubMed:12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed:11524461). {ECO:0000269|PubMed:11524461, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:8505626}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|K tetra|
|Ion trans 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intracellular canaliculus|
|membrane repolarization during bundle of His cell action potential|
|voltage-gated potassium channel activity involved in SA node cell action potential repolarization|
|voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization|
|membrane repolarization during SA node cell action potential|
|voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization|
|bundle of His cell action potential|
|bundle of His cell to Purkinje myocyte signaling|
|membrane repolarization during atrial cardiac muscle cell action potential|
|atrial cardiac muscle cell membrane repolarization|
|potassium channel complex|
|regulation of atrial cardiac muscle cell membrane repolarization|
|positive regulation of myoblast proliferation|
|SA node cell action potential|
|SA node cell to atrial cardiac muscle cell signaling|
|SA node cell to atrial cardiac muscle cell communication|
|membrane hyperpolarization|
|negative regulation of cytosolic calcium ion concentration|
|outward rectifier potassium channel activity|
|bundle of His cell to Purkinje myocyte communication|
|regulation of myoblast proliferation|
|atrial cardiac muscle cell to AV node cell signaling|
|atrial cardiac muscle cell action potential|
|potassium ion export across plasma membrane|
|atrial cardiac muscle cell to AV node cell communication|
|alpha-actinin binding|
|membrane repolarization during action potential|
|membrane repolarization during cardiac muscle cell action potential|
|cardiac muscle cell membrane repolarization|
|response to hyperoxia|
|membrane repolarization|
|regulation of cardiac muscle cell membrane repolarization|
|cell-cell signaling involved in cardiac conduction|
|response to increased oxygen levels|
|potassium ion homeostasis|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|positive regulation of G1/S transition of mitotic cell cycle|
|regulation of heart rate by cardiac conduction|
|cardiac muscle cell action potential involved in contraction|
|export across plasma membrane|
|cardiac muscle cell contraction|
|cell communication involved in cardiac conduction|
|intercalated disc|
|positive regulation of cell cycle G1/S phase transition|
|cardiac muscle cell action potential|
|regulation of vasoconstriction|
|scaffold protein binding|
|voltage-gated potassium channel activity|
|caveola|
|positive regulation of mitotic cell cycle phase transition|
|cardiac muscle contraction|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|positive regulation of cell cycle phase transition|
|action potential|
|regulation of potassium ion transport|
|regulation of heart rate|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|response to hydrogen peroxide|
|Notch signaling pathway|
|Z disc|
|multicellular organismal signaling|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|monovalent inorganic cation homeostasis|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|potassium ion transmembrane transport|
|regulation of cell cycle G1/S phase transition|
|potassium ion transport|
|vascular process in circulatory system|
|regulation of insulin secretion|
|response to reactive oxygen species|
|regulation of peptide hormone secretion|
|response to mechanical stimulus|
|membrane raft|
|regulation of heart contraction|
|muscle contraction|
|regulation of hormone secretion|
|positive regulation of cell cycle process|
|regulation of blood circulation|
|muscle system process|
|response to antibiotic|
|regulation of cytosolic calcium ion concentration|
|signaling receptor binding|
|protein homooligomerization|
|response to hypoxia|
|response to decreased oxygen levels|
|positive regulation of cell cycle|
|response to oxygen levels|
|response to oxidative stress|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of mitotic cell cycle phase transition|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|regulation of cell cycle phase transition|
|calcium ion homeostasis|
|protein kinase binding|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|response to toxic substance|
|regulation of anatomical structure size|
|protein complex oligomerization|
|regulation of hormone levels|
|response to inorganic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|regulation of mitotic cell cycle|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of protein transport|
|cation homeostasis|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of cell cycle process|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|Golgi apparatus|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|export from cell|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|regulation of cell cycle|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of cell population proliferation|
|homeostatic process|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16233
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNA5 Expression in NALM6 Cells: -1.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>