KCNC1 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNC1
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily C member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3746|3746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48547|P48547]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176258|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a family of integral membrane proteins that mediate the voltage-dependent potassium ion permeability of excitable membranes. Alternative splicing is thought to result in two transcript variants encoding isoforms that differ at their C-termini. These isoforms have had conflicting names in the literature: the longer isoform has been called both 'b' and 'alpha', while the shorter isoform has been called both 'a' and 'beta' (PMIDs 1432046, 12091563). [provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:25401298). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons. {ECO:0000250|UniProtKB:P25122, ECO:0000269|PubMed:25401298}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
|K tetra|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential|
|globus pallidus development|
|regulation of presynaptic membrane potential|
|response to light intensity|
|axolemma|
|positive regulation of voltage-gated potassium channel activity|
|response to potassium ion|
|positive regulation of potassium ion transmembrane transporter activity|
|calyx of Held|
|response to auditory stimulus|
|neuronal cell body membrane|
|dendrite membrane|
|delayed rectifier potassium channel activity|
|positive regulation of potassium ion transmembrane transport|
|kinesin binding|
|positive regulation of potassium ion transport|
|integral component of postsynaptic membrane|
|response to amine|
|response to nerve growth factor|
|regulation of potassium ion transmembrane transporter activity|
|integral component of presynaptic membrane|
|voltage-gated potassium channel activity|
|neural nucleus development|
|positive regulation of cation channel activity|
|diencephalon development|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|regulation of potassium ion transport|
|cerebellum development|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|metencephalon development|
|response to fibroblast growth factor|
|ion channel binding|
|positive regulation of cation transmembrane transport|
|protein tetramerization|
|hindbrain development|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|response to mechanical stimulus|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|axon|
|response to light stimulus|
|regulation of cation transmembrane transport|
|protein homooligomerization|
|response to metal ion|
|neuronal cell body|
|regulation of metal ion transport|
|forebrain development|
|monovalent inorganic cation transport|
|cellular response to drug|
|regulation of membrane potential|
|response to radiation|
|regulation of ion transmembrane transport|
|response to toxic substance|
|protein complex oligomerization|
|response to growth factor|
|response to inorganic substance|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of ion transport|
|brain development|
|head development|
|cation transport|
|ion transmembrane transport|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|protein-containing complex assembly|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.72|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.529|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14381
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.31 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNC1 Expression in NALM6 Cells: -2.31'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>