KCNC2 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNC2
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily C member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3747|3747]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PR1|Q96PR1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176256|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly. Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:15709110). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 or KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG- mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (By similarity). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:15709110). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). {ECO:0000250|UniProtKB:P22462, ECO:0000250|UniProtKB:Q14B80, ECO:0000269|PubMed:15709110, ECO:0000305|PubMed:10414303, ECO:0000305|PubMed:11506885}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
|K tetra|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nitric oxide-cGMP-mediated signaling pathway|
|voltage-gated ion channel activity involved in regulation of presynaptic membrane potential|
|globus pallidus development|
|regulation of presynaptic membrane potential|
|response to light intensity|
|axolemma|
|positive regulation of voltage-gated potassium channel activity|
|cellular response to nitric oxide|
|response to nitric oxide|
|cellular response to reactive nitrogen species|
|response to magnesium ion|
|nitric oxide mediated signal transduction|
|positive regulation of potassium ion transmembrane transporter activity|
|cGMP-mediated signaling|
|neuronal cell body membrane|
|dendrite membrane|
|delayed rectifier potassium channel activity|
|positive regulation of potassium ion transmembrane transport|
|positive regulation of potassium ion transport|
|response to amine|
|terminal bouton|
|response to bronchodilator|
|response to nerve growth factor|
|regulation of potassium ion transmembrane transporter activity|
|voltage-gated potassium channel activity|
|neural nucleus development|
|positive regulation of cation channel activity|
|presynaptic membrane|
|diencephalon development|
|regulation of potassium ion transmembrane transport|
|voltage-gated potassium channel complex|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|protein heterooligomerization|
|positive regulation of transporter activity|
|ion channel binding|
|response to ethanol|
|cellular response to ammonium ion|
|cellular response to reactive oxygen species|
|perikaryon|
|vesicle|
|positive regulation of cation transmembrane transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|regulation of insulin secretion|
|response to ammonium ion|
|response to reactive oxygen species|
|basolateral plasma membrane|
|postsynaptic membrane|
|positive regulation of transmembrane transport|
|regulation of peptide hormone secretion|
|cellular response to toxic substance|
|cellular response to inorganic substance|
|response to alcohol|
|cellular response to oxidative stress|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|synapse|
|positive regulation of ion transport|
|regulation of transporter activity|
|axon|
|response to antibiotic|
|response to light stimulus|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|protein homooligomerization|
|response to metal ion|
|neuronal cell body|
|response to oxidative stress|
|forebrain development|
|regulation of metal ion transport|
|monovalent inorganic cation transport|
|cellular response to drug|
|dendrite|
|regulation of membrane potential|
|response to radiation|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|regulation of peptide secretion|
|response to toxic substance|
|protein complex oligomerization|
|response to growth factor|
|regulation of hormone levels|
|response to inorganic substance|
|cell junction|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|head development|
|regulation of secretion|
|cation transport|
|response to organic cyclic compound|
|ion transmembrane transport|
|central nervous system development|
|positive regulation of transport|
|response to organonitrogen compound|
|response to drug|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of molecular function|
|protein-containing complex subunit organization|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.459|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6615
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.16 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNC2 Expression in NALM6 Cells: -1.16'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>