KCNE1 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNE1
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily E regulatory subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3753|3753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15382|P15382]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/176261|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed:19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). {ECO:0000269|PubMed:19219384}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ISK Channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein targeting to membrane|
|voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization|
|telethonin binding|
|negative regulation of delayed rectifier potassium channel activity|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|negative regulation of voltage-gated potassium channel activity|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|ventricular cardiac muscle cell membrane repolarization|
|potassium ion export across plasma membrane|
|cardiac muscle cell membrane repolarization|
|regulation of delayed rectifier potassium channel activity|
|membrane repolarization during action potential|
|membrane repolarization during cardiac muscle cell action potential|
|negative regulation of potassium ion transmembrane transporter activity|
|membrane repolarization|
|ventricular cardiac muscle cell action potential|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell membrane repolarization|
|negative regulation of protein localization to membrane|
|negative regulation of potassium ion transport|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|regulation of protein targeting to membrane|
|positive regulation of potassium ion transmembrane transport|
|regulation of heart rate by cardiac conduction|
|export across plasma membrane|
|cardiac muscle cell action potential involved in contraction|
|potassium channel regulator activity|
|negative regulation of intracellular protein transport|
|cardiac muscle cell contraction|
|negative regulation of cation channel activity|
|positive regulation of potassium ion transport|
|cardiac muscle cell action potential|
|cellular response to cAMP|
|regulation of potassium ion transmembrane transporter activity|
|voltage-gated potassium channel activity|
|negative regulation of intracellular transport|
|negative regulation of ion transmembrane transporter activity|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|regulation of protein targeting|
|voltage-gated potassium channel complex|
|heart contraction|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|regulation of potassium ion transport|
|negative regulation of ion transmembrane transport|
|regulation of heart rate|
|response to cAMP|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|negative regulation of cellular protein localization|
|negative regulation of transmembrane transport|
|ion channel binding|
|Z disc|
|multicellular organismal signaling|
|response to organophosphorus|
|positive regulation of cation transmembrane transport|
|sensory perception of sound|
|negative regulation of ion transport|
|response to purine-containing compound|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|sensory perception of mechanical stimulus|
|potassium ion transport|
|regulation of cation channel activity|
|negative regulation of protein transport|
|negative regulation of establishment of protein localization|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|membrane raft|
|regulation of intracellular protein transport|
|regulation of heart contraction|
|muscle contraction|
|lysosome|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of blood circulation|
|muscle system process|
|apical plasma membrane|
|regulation of cation transmembrane transport|
|regulation of intracellular transport|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of cellular protein localization|
|cellular response to organic cyclic compound|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|cation transport|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|positive regulation of transport|
|response to organonitrogen compound|
|regulation of protein localization|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|negative regulation of molecular function|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|response to endogenous stimulus|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13048
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNE1 Expression in NALM6 Cells: 2.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>