KCNE2 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNE2
  * **<color #00a2e8>Official Name</color>**: potassium voltage-gated channel subfamily E regulatory subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9992|9992]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6J6|Q9Y6J6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603796|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with HCN1 and HCN2 and increase potassium current. Interacts with KCNQ1; forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). {ECO:0000250|UniProtKB:P63161, ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:11101505}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ISK Channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cyclic nucleotide-gated ion channel activity|
|regulation of inward rectifier potassium channel activity|
|negative regulation of delayed rectifier potassium channel activity|
|ventricular cardiac muscle cell membrane repolarization|
|voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization|
|negative regulation of voltage-gated potassium channel activity|
|positive regulation of voltage-gated calcium channel activity|
|membrane repolarization during ventricular cardiac muscle cell action potential|
|potassium ion export across plasma membrane|
|membrane repolarization during cardiac muscle cell action potential|
|membrane repolarization during action potential|
|regulation of delayed rectifier potassium channel activity|
|cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transporter activity|
|tongue development|
|inward rectifier potassium channel activity|
|ventricular cardiac muscle cell action potential|
|membrane repolarization|
|regulation of ventricular cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transmembrane transport|
|regulation of cardiac muscle cell membrane repolarization|
|negative regulation of potassium ion transport|
|delayed rectifier potassium channel activity|
|regulation of membrane repolarization|
|regulation of voltage-gated calcium channel activity|
|regulation of heart rate by cardiac conduction|
|positive regulation of calcium ion transmembrane transporter activity|
|cardiac muscle cell action potential involved in contraction|
|export across plasma membrane|
|potassium channel regulator activity|
|cardiac muscle cell contraction|
|negative regulation of cation channel activity|
|potassium ion import across plasma membrane|
|cardiac muscle cell action potential|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|negative regulation of ion transmembrane transporter activity|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|cardiac muscle contraction|
|negative regulation of transporter activity|
|regulation of potassium ion transmembrane transport|
|negative regulation of cation transmembrane transport|
|voltage-gated potassium channel complex|
|heart contraction|
|regulation of calcium ion transmembrane transporter activity|
|actin-mediated cell contraction|
|cardiac conduction|
|action potential|
|negative regulation of ion transmembrane transport|
|regulation of potassium ion transport|
|regulation of heart rate|
|import across plasma membrane|
|heart process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of ion transmembrane transporter activity|
|striated muscle contraction|
|actin filament-based movement|
|positive regulation of transporter activity|
|negative regulation of transmembrane transport|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of calcium ion transport|
|ion channel binding|
|multicellular organismal signaling|
|positive regulation of cellular protein catabolic process|
|positive regulation of cation transmembrane transport|
|regulation of calcium ion transmembrane transport|
|negative regulation of ion transport|
|positive regulation of ion transmembrane transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cation channel activity|
|regulation of proteasomal protein catabolic process|
|positive regulation of transmembrane transport|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of heart contraction|
|regulation of cellular protein catabolic process|
|regulation of calcium ion transport|
|muscle contraction|
|lysosome|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|aging|
|regulation of blood circulation|
|muscle system process|
|regulation of cation transmembrane transport|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|cellular response to drug|
|regulation of membrane potential|
|positive regulation of catabolic process|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|sensory organ development|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|actin filament-based process|
|regulation of system process|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|regulation of ion transport|
|regulation of proteolysis|
|cation transport|
|regulation of cellular catabolic process|
|protein homodimerization activity|
|ion transmembrane transport|
|Golgi apparatus|
|positive regulation of transport|
|regulation of catabolic process|
|endoplasmic reticulum|
|response to drug|
|export from cell|
|negative regulation of molecular function|
|transmembrane transport|
|ion transport|
|movement of cell or subcellular component|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-1.74|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|1.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7679
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNE2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>