KCNK4 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNK4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNK4
  * **<color #00a2e8>Official Name</color>**: potassium two pore domain channel subfamily K member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=50801|50801]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYG8|Q9NYG8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNK4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNK4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). {ECO:0000250|UniProtKB:G3V8V5, ECO:0000250|UniProtKB:O88454, ECO:0000269|PubMed:22282805, ECO:0000269|PubMed:25471887, ECO:0000269|PubMed:25500157}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mechanosensitived potassium channel activity|
|temperature-gated cation channel activity|
|cellular response to alkaline pH|
|detection of mechanical stimulus involved in sensory perception of touch|
|response to alkaline pH|
|sensory perception of touch|
|cellular response to temperature stimulus|
|potassium channel complex|
|potassium ion leak channel activity|
|stabilization of membrane potential|
|sensory perception of temperature stimulus|
|cellular response to pH|
|potassium channel activity|
|detection of mechanical stimulus involved in sensory perception|
|response to pH|
|voltage-gated ion channel activity|
|detection of mechanical stimulus|
|cellular response to fatty acid|
|sensory perception of pain|
|cellular response to mechanical stimulus|
|response to fatty acid|
|memory|
|detection of external stimulus|
|detection of abiotic stimulus|
|potassium ion transmembrane transport|
|sensory perception of mechanical stimulus|
|potassium ion transport|
|response to temperature stimulus|
|cellular response to acid chemical|
|response to mechanical stimulus|
|learning or memory|
|cognition|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|cellular response to external stimulus|
|response to acid chemical|
|monovalent inorganic cation transport|
|regulation of membrane potential|
|regulation of ion transmembrane transport|
|cellular response to lipid|
|detection of stimulus involved in sensory perception|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|behavior|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|detection of stimulus|
|regulation of ion transport|
|cation transport|
|response to lipid|
|ion transmembrane transport|
|sensory perception|
|cellular response to oxygen-containing compound|
|response to abiotic stimulus|
|transmembrane transport|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|response to oxygen-containing compound|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2772
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNK4 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>