KCNN4 [The Human Chemical-Genetic Interaction Map Project]

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======= KCNN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KCNN4
  * **<color #00a2e8>Official Name</color>**: potassium calcium-activated channel subfamily N member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3783|3783]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15554|O15554]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KCNN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KCNN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602754|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin (PubMed:17157250, PubMed:18796614). {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614, ECO:0000269|PubMed:26148990}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans 2|
|CaMBD|
|SK channel|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Intermediate conductance calcium-activated potassium channel activity|
|small conductance calcium-activated potassium channel activity|
|saliva secretion|
|calcium-activated potassium channel activity|
|positive regulation of T cell receptor signaling pathway|
|stabilization of membrane potential|
|secretion by tissue|
|positive regulation of antigen receptor-mediated signaling pathway|
|cell volume homeostasis|
|potassium channel activity|
|regulation of T cell receptor signaling pathway|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|regulation of antigen receptor-mediated signaling pathway|
|body fluid secretion|
|digestive system process|
|voltage-gated potassium channel complex|
|protein phosphatase binding|
|phospholipid transport|
|digestion|
|organophosphate ester transport|
|vesicle|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cell size|
|calmodulin binding|
|calcium ion transport|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|lipid transport|
|divalent inorganic cation transport|
|neuron projection|
|lipid localization|
|neuronal cell body|
|regulation of cellular component size|
|monovalent inorganic cation transport|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of anatomical structure size|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|cation transport|
|membrane organization|
|positive regulation of immune response|
|cellular homeostasis|
|ion transmembrane transport|
|positive regulation of transport|
|regulation of protein localization|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|transmembrane transport|
|defense response|
|ion transport|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|-2.55|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.1|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4007
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KCNN4 Expression in NALM6 Cells: 4.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>