KDM3A [The Human Chemical-Genetic Interaction Map Project]

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======= KDM3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM3A
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 3A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55818|55818]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y4C1|Q9Y4C1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDM3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDM3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611512|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Histone demethylase that specifically demethylates 'Lys- 9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|JmjC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|formaldehyde biosynthetic process|
|histone H3-K9 dimethylation|
|formaldehyde metabolic process|
|spermatid nucleus elongation|
|aldehyde biosynthetic process|
|negative regulation of histone H3-K9 methylation|
|antibiotic biosynthetic process|
|peptidyl-lysine dimethylation|
|histone demethylase activity (H3-K9 specific)|
|histone H3-K9 methylation|
|histone H3-K9 demethylation|
|histone H3-K9 modification|
|negative regulation of histone methylation|
|spermatid nucleus differentiation|
|regulation of histone H3-K9 methylation|
|dioxygenase activity|
|regulation of stem cell population maintenance|
|histone lysine demethylation|
|histone demethylation|
|protein dealkylation|
|protein demethylation|
|RNA polymerase II core promoter sequence-specific DNA binding|
|androgen receptor signaling pathway|
|negative regulation of histone modification|
|androgen receptor binding|
|cellular aldehyde metabolic process|
|negative regulation of chromatin organization|
|demethylation|
|regulation of histone methylation|
|intracellular steroid hormone receptor signaling pathway|
|chromatin DNA binding|
|histone lysine methylation|
|transcription regulatory region sequence-specific DNA binding|
|peptidyl-lysine methylation|
|histone methylation|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|positive regulation of cold-induced thermogenesis|
|antibiotic metabolic process|
|chromatin|
|regulation of stem cell differentiation|
|steroid hormone mediated signaling pathway|
|nucleus organization|
|iron ion binding|
|protein methylation|
|protein alkylation|
|negative regulation of chromosome organization|
|regulation of cold-induced thermogenesis|
|regulation of histone modification|
|spermatid development|
|spermatid differentiation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|cellular response to steroid hormone stimulus|
|regulation of chromatin organization|
|macromolecule methylation|
|germ cell development|
|methylation|
|peptidyl-lysine modification|
|response to steroid hormone|
|regulation of chromosome organization|
|cellular process involved in reproduction in multicellular organism|
|histone modification|
|negative regulation of organelle organization|
|covalent chromatin modification|
|drug metabolic process|
|cellular response to lipid|
|cellular response to organic cyclic compound|
|spermatogenesis|
|male gamete generation|
|small molecule biosynthetic process|
|negative regulation of protein modification process|
|cellular response to hormone stimulus|
|developmental process involved in reproduction|
|DNA-binding transcription factor activity|
|gamete generation|
|chromatin organization|
|negative regulation of cellular component organization|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|peptidyl-amino acid modification|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|multi-organism reproductive process|
|cellular response to cytokine stimulus|
|negative regulation of cellular protein metabolic process|
|chromosome organization|
|response to cytokine|
|negative regulation of protein metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|regulation of organelle organization|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDM3A Expression in NALM6 Cells: 6.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>