KDM8 [The Human Chemical-Genetic Interaction Map Project]

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======= KDM8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KDM8
  * **<color #00a2e8>Official Name</color>**: lysine demethylase 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79831|79831]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N371|Q8N371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KDM8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KDM8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Histone demethylase required for G2/M phase cell cycle progression (PubMed:20457893). Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator (PubMed:20457893). Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation (PubMed:20457893). In a complex with coregulator RCCD1, is also able to demethylate trimethylated 'Lys-36' (H3K36me3) of histone H3 (PubMed:24981860). Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1 (PubMed:24981860). Possibly together with RCCD1, involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability (PubMed:28455245). Might function as a protein hydroxylase (PubMed:22851697, PubMed:24100311). Under stress conditions that cause a DNA damage response, acts as a histone protease by cleaving the N-terminal tail of histone H3 at the carboxyl side of monomethyl-lysine (Kme1) residues, preferably at monomethylated 'Lys-9' (H3K9me1) (PubMed:28982940). The histone variant H3F3A is the major target for cleavage (PubMed:28982940). {ECO:0000269|PubMed:20457893, ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245, ECO:0000269|PubMed:28982940, ECO:0000303|PubMed:22851697, ECO:0000303|PubMed:24100311}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cupin 4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K36 demethylation|
|histone demethylase activity (H3-K36 specific)|
|2-oxoglutarate-dependent dioxygenase activity|
|histone lysine demethylation|
|aminopeptidase activity|
|histone demethylation|
|protein dealkylation|
|protein demethylation|
|protein destabilization|
|methylated histone binding|
|circadian regulation of gene expression|
|demethylation|
|endopeptidase activity|
|chromosome|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|circadian rhythm|
|mitotic cell cycle phase transition|
|rhythmic process|
|cell cycle phase transition|
|regulation of protein stability|
|histone modification|
|covalent chromatin modification|
|chromatin binding|
|mitotic cell cycle process|
|mitotic cell cycle|
|chromatin organization|
|oxidation-reduction process|
|cell cycle process|
|chromosome organization|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-2.04|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.96|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|-1.93|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.91|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.89|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.86|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.84|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.82|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.74|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.74|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.71|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.75|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.76|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.77|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.78|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.83|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|1.84|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.88|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.97|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.12|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.19|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.27|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpp21|RPP21]]|0.479|
|[[:human genes:u:urm1|URM1]]|0.478|
|[[:human genes:c:cxorf56|CXorf56]]|0.47|
|[[:human genes:g:gemin8|GEMIN8]]|0.459|
|[[:human genes:t:thg1l|THG1L]]|0.45|
|[[:human genes:p:pdcd6ip|PDCD6IP]]|0.447|
|[[:human genes:z:znhit1|ZNHIT1]]|0.447|
|[[:human genes:a:adsl|ADSL]]|0.447|
|[[:human genes:w:wdr82|WDR82]]|0.444|
|[[:human genes:v:vezt|VEZT]]|0.441|
|[[:human genes:r:rabggtb|RABGGTB]]|0.439|
|[[:human genes:a:alg1|ALG1]]|0.438|
|[[:human genes:e:exoc4|EXOC4]]|0.435|
|[[:human genes:d:ddx55|DDX55]]|0.434|
|[[:human genes:u:uap1|UAP1]]|0.431|
|[[:human genes:c:c14orf80|C14orf80]]|0.429|
|[[:human genes:u:utp23|UTP23]]|0.429|
|[[:human genes:e:elp6|ELP6]]|0.429|
|[[:human genes:e:elp3|ELP3]]|0.428|
|[[:human genes:g:gemin6|GEMIN6]]|0.426|
|[[:human genes:p:pmm2|PMM2]]|0.423|
|[[:human genes:s:srpk1|SRPK1]]|0.422|
|[[:human genes:r:rpe|RPE]]|0.422|
|[[:human genes:d:ddx20|DDX20]]|0.417|
|[[:human genes:e:elp2|ELP2]]|0.417|
|[[:human genes:s:slc25a19|SLC25A19]]|0.415|
|[[:human genes:t:tpi1|TPI1]]|0.411|
|[[:human genes:d:dpagt1|DPAGT1]]|0.41|
|[[:human genes:p:ppp6c|PPP6C]]|0.405|
|[[:human genes:g:gmppb|GMPPB]]|0.404|
|[[:human genes:c:ctu1|CTU1]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 57/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|3/28|
|bone|4/25|
|breast|1/33|
|central nervous system|9/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/15|
|kidney|2/21|
|liver|2/20|
|lung|7/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|1/7|
|thyroid|0/2|
|upper aerodigestive|4/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3098
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KDM8 Expression in NALM6 Cells: 3.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>