KIAA0195 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA0195 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM94
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 94
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9772|9772]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12767|Q12767]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA0195&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA0195|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618163|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cation ATPase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.3|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-1.9|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.7|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|1.7|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.75|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|1.88|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.89|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.95|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.01|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.19|
|[[:results:exp433|LJH685 50μM R08 exp433]]|2.23|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|2.46|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.58|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.63|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.71|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:f:fibp|FIBP]]|0.585|
|[[:human genes:c:c2cd5|C2CD5]]|0.449|
|[[:human genes:c:cdk5|CDK5]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA0195 Expression in NALM6 Cells: 6.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>