KIAA1432 [The Human Chemical-Genetic Interaction Map Project]

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======= KIAA1432 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: RIC1
  * **<color #00a2e8>Official Name</color>**: RIC1 homolog, RAB6A GEF complex partner 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57589|57589]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4ADV7|Q4ADV7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIAA1432&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIAA1432|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610354|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RIC1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RIC1-RGP1 guanyl-nucleotide exchange factor complex|
|Rab guanyl-nucleotide exchange factor activity|
|negative regulation of cellular protein catabolic process|
|trans-Golgi network membrane|
|retrograde transport, endosome to Golgi|
|negative regulation of protein catabolic process|
|cytosolic transport|
|Rab GTPase binding|
|endosomal transport|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|positive regulation of GTPase activity|
|regulation of GTPase activity|
|protein-containing complex|
|Golgi membrane|
|positive regulation of hydrolase activity|
|regulation of cellular catabolic process|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|regulation of hydrolase activity|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-4.63|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.25|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-3.24|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-3.24|
|[[:results:exp495|IWR1 50μM R08 exp495]]|-2.91|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-2.83|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.76|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.64|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-2.63|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-2.63|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-2.61|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.53|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.48|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.47|
|[[:results:exp11|CCCP 1μM R00 exp11]]|-2.46|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.43|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.42|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-2.41|
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.39|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|-2.38|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.35|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.32|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.29|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.28|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2.27|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-2.25|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.21|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|-2.2|
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-2.19|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-2.19|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.18|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-2.16|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.16|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-2.14|
|[[:results:exp453|B02 10μM R08 exp453]]|-2.12|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.12|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|-2.11|
|[[:results:exp219|A-395N 10μM R05 exp219]]|-2.09|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-2.07|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-2.06|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|-2.06|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-2.06|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.06|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-2.06|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.06|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.05|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.04|
|[[:results:exp457|Bisphenol F 50μM R08 exp457]]|-2|
|[[:results:exp392|PT-1 25μM R07 exp392]]|-1.97|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.96|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.95|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.94|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.93|
|[[:results:exp422|Wiskostatin 3μM R07 exp422]]|-1.93|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.92|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.92|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.9|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.88|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.86|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-1.86|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.84|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.84|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-1.83|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.82|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.81|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|-1.81|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.81|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-1.8|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.79|
|[[:results:exp303|39°C R06 exp303]]|-1.78|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.78|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.77|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.76|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.74|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.72|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.71|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.71|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-1.71|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.7|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.8|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|3.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:scap|SCAP]]|0.543|
|[[:human genes:r:rgp1|RGP1]]|0.542|
|[[:human genes:m:mbtps1|MBTPS1]]|0.5|
|[[:human genes:c:cept1|CEPT1]]|0.45|
|[[:human genes:u:uso1|USO1]]|0.444|
|[[:human genes:m:mbtps2|MBTPS2]]|0.441|
|[[:human genes:u:unc50|UNC50]]|0.438|
|[[:human genes:c:cog5|COG5]]|0.43|
|[[:human genes:a:arl1|ARL1]]|0.428|
|[[:human genes:r:rab1b|RAB1B]]|0.42|
|[[:human genes:g:gpr107|GPR107]]|0.413|
|[[:human genes:k:kdsr|KDSR]]|0.41|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 228/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|16/28|
|blood|10/28|
|bone|6/26|
|breast|7/33|
|central nervous system|19/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|8/13|
|fibroblast|0/1|
|gastric|6/16|
|kidney|8/21|
|liver|4/20|
|lung|24/75|
|lymphocyte|11/16|
|ovary|5/26|
|pancreas|11/24|
|peripheral nervous system|2/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|0/2|
|upper aerodigestive|11/22|
|urinary tract|7/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3346
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIAA1432 Expression in NALM6 Cells: 7.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>