KIF16B [The Human Chemical-Genetic Interaction Map Project]

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======= KIF16B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF16B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 16B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55614|55614]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96L93|Q96L93]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF16B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF16B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618171|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a kinesin-like protein that may be involved in intracellular trafficking. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PX|
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Golgi to endosome transport|
|early endosome to late endosome transport|
|regulation of receptor recycling|
|vesicle-mediated transport between endosomal compartments|
|ATP-dependent microtubule motor activity, plus-end-directed|
|receptor catabolic process|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|phosphatidylinositol-3,4,5-trisphosphate binding|
|phosphatidylinositol-3-phosphate binding|
|epidermal growth factor receptor signaling pathway|
|kinesin complex|
|phagocytic vesicle|
|microtubule motor activity|
|ERBB signaling pathway|
|endoderm development|
|fibroblast growth factor receptor signaling pathway|
|post-Golgi vesicle-mediated transport|
|receptor metabolic process|
|cellular response to fibroblast growth factor stimulus|
|formation of primary germ layer|
|response to fibroblast growth factor|
|cytosolic transport|
|Rab GTPase binding|
|early endosome membrane|
|gastrulation|
|cellular response to interferon-gamma|
|response to interferon-gamma|
|ATPase activity|
|microtubule binding|
|early endosome|
|endosome|
|microtubule-based movement|
|microtubule|
|Golgi vesicle transport|
|cellular response to growth factor stimulus|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|response to growth factor|
|embryonic morphogenesis|
|microtubule-based process|
|enzyme linked receptor protein signaling pathway|
|innate immune response|
|anatomical structure formation involved in morphogenesis|
|defense response to other organism|
|embryo development|
|cellular response to cytokine stimulus|
|macromolecule catabolic process|
|response to cytokine|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|response to endogenous stimulus|
|ATP binding|
|intracellular transport|
|movement of cell or subcellular component|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.04|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10242
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF16B Expression in NALM6 Cells: 4.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>