KIF20B [The Human Chemical-Genetic Interaction Map Project]

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======= KIF20B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF20B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 20B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9585|9585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96Q89|Q96Q89]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF20B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF20B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605498|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mitotic cytokinetic process|
|positive regulation of mitotic cytokinesis|
|regulation of mitotic cytokinetic process|
|regulation of cytokinetic process|
|contractile ring|
|regulation of mitotic cytokinesis|
|protein localization to microtubule|
|mitotic spindle midzone|
|positive regulation of neuron migration|
|regulation of establishment of cell polarity|
|regulation of establishment or maintenance of cell polarity|
|spindle midzone|
|ATP-dependent microtubule motor activity, plus-end-directed|
|mitotic spindle pole|
|WW domain binding|
|protein localization to microtubule cytoskeleton|
|positive regulation of cytokinesis|
|protein localization to cytoskeleton|
|regulation of neuron migration|
|kinesin complex|
|microtubule motor activity|
|positive regulation of cell division|
|regulation of cytokinesis|
|neural tube closure|
|tube closure|
|primary neural tube formation|
|neural tube formation|
|embryonic epithelial tube formation|
|growth cone|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|cell cycle arrest|
|tube formation|
|positive regulation of mitotic cell cycle|
|positive regulation of intracellular protein transport|
|midbody|
|neural tube development|
|regulation of cell division|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|ATPase activity|
|microtubule binding|
|microtubule-based movement|
|positive regulation of cell cycle process|
|epithelial tube morphogenesis|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of cell cycle|
|positive regulation of protein transport|
|morphogenesis of an epithelium|
|positive regulation of establishment of protein localization|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|centrosome|
|cell division|
|positive regulation of cell migration|
|cell part morphogenesis|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of locomotion|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of cell cycle|
|regulation of mitotic cell cycle|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|microtubule-based process|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|cell morphogenesis|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|nucleolus|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|cell cycle process|
|neuron differentiation|
|regulation of protein localization|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF20B Expression in NALM6 Cells: 7.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>