KIF5B [The Human Chemical-Genetic Interaction Map Project]

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======= KIF5B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIF5B
  * **<color #00a2e8>Official Name</color>**: kinesin family member 5B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3799|3799]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P33176|P33176]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIF5B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIF5B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602809|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). {ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kinesin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of voltage-gated sodium channel activity|
|microtubule lateral binding|
|regulation of voltage-gated sodium channel activity|
|anterograde neuronal dense core vesicle transport|
|stress granule disassembly|
|retrograde neuronal dense core vesicle transport|
|dense core granule cytoskeletal transport|
|dense core granule transport|
|dense core granule localization|
|plus-end-directed vesicle transport along microtubule|
|JUN kinase binding|
|plus-end-directed organelle transport along microtubule|
|protein localization to presynapse|
|anterograde axonal protein transport|
|cytoplasm organization|
|secretory granule localization|
|ciliary rootlet|
|positive regulation of vesicle fusion|
|positive regulation of synaptic transmission, GABAergic|
|axo-dendritic protein transport|
|ribonucleoprotein complex disassembly|
|positive regulation of sodium ion transmembrane transporter activity|
|retrograde axonal transport|
|positive regulation of sodium ion transmembrane transport|
|axonal growth cone|
|centrosome localization|
|microtubule organizing center localization|
|regulation of vesicle fusion|
|regulation of synaptic transmission, GABAergic|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|positive regulation of sodium ion transport|
|anterograde axonal transport|
|vesicle transport along microtubule|
|positive regulation of potassium ion transport|
|vesicle cytoskeletal trafficking|
|kinesin complex|
|regulation of sodium ion transmembrane transporter activity|
|positive regulation of protein localization to plasma membrane|
|axonal transport|
|axon cytoplasm|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|phagocytic vesicle|
|positive regulation of protein localization to cell periphery|
|regulation of sodium ion transmembrane transport|
|protein localization to synapse|
|organelle disassembly|
|axo-dendritic transport|
|microtubule motor activity|
|protein transport along microtubule|
|microtubule-based protein transport|
|positive regulation of cation channel activity|
|positive regulation of insulin secretion|
|organelle transport along microtubule|
|hippocampus development|
|regulation of sodium ion transport|
|regulation of protein localization to plasma membrane|
|regulation of potassium ion transport|
|positive regulation of peptide hormone secretion|
|positive regulation of ion transmembrane transporter activity|
|limbic system development|
|positive regulation of transporter activity|
|regulation of protein localization to cell periphery|
|positive regulation of protein localization to membrane|
|positive regulation of hormone secretion|
|vesicle|
|positive regulation of cation transmembrane transport|
|cytosolic transport|
|positive regulation of synaptic transmission|
|positive regulation of intracellular protein transport|
|positive regulation of ion transmembrane transport|
|transport along microtubule|
|microtubule organizing center|
|cellular response to interferon-gamma|
|regulation of cation channel activity|
|pallium development|
|establishment of vesicle localization|
|cytoskeleton-dependent intracellular transport|
|regulation of insulin secretion|
|response to interferon-gamma|
|microtubule-based transport|
|vesicle localization|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|positive regulation of intracellular transport|
|regulation of peptide hormone secretion|
|regulation of intracellular protein transport|
|ATPase activity|
|microtubule binding|
|protein-containing complex disassembly|
|ribonucleoprotein complex subunit organization|
|regulation of ion transmembrane transporter activity|
|telencephalon development|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|microtubule-based movement|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of peptide secretion|
|cadherin binding|
|microtubule|
|positive regulation of cellular protein localization|
|regulation of cation transmembrane transport|
|regulation of intracellular transport|
|establishment of organelle localization|
|regulation of metal ion transport|
|forebrain development|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|regulation of membrane potential|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of ion transmembrane transport|
|regulation of peptide secretion|
|regulation of hormone levels|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|organelle localization|
|positive regulation of organelle organization|
|microtubule-based process|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|innate immune response|
|head development|
|regulation of secretion|
|regulation of cellular localization|
|defense response to other organism|
|central nervous system development|
|positive regulation of transport|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|identical protein binding|
|response to cytokine|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIF5B Expression in NALM6 Cells: 8.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>