KIN [The Human Chemical-Genetic Interaction Map Project]

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======= KIN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIN
  * **<color #00a2e8>Official Name</color>**: Kin17 DNA and RNA binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22944|22944]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60870|O60870]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601720|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kin17 mid|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|double-stranded DNA binding|
|nuclear matrix|
|DNA replication|
|DNA recombination|
|mRNA processing|
|DNA repair|
|protein-containing complex|
|intracellular membrane-bounded organelle|
|mRNA metabolic process|
|viral process|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|symbiotic process|
|interspecies interaction between organisms|
|RNA processing|
|RNA binding|
|DNA binding|
|RNA metabolic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.83|
|[[:results:exp453|B02 10μM R08 exp453]]|1.71|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.83|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.86|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.88|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.89|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.02|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.19|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psma6|PSMA6]]|0.435|
|[[:human genes:p:psmb4|PSMB4]]|0.424|
|[[:human genes:p:polr2j3|POLR2J3]]|0.42|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.413|
|[[:human genes:c:copg1|COPG1]]|0.411|
|[[:human genes:c:cdc5l|CDC5L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 582/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|21/28|
|bone|22/26|
|breast|20/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|16/17|
|esophagus|11/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|12/21|
|liver|9/20|
|lung|60/75|
|lymphocyte|15/16|
|ovary|22/26|
|pancreas|19/24|
|peripheral nervous system|14/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|18/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 745
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIN Expression in NALM6 Cells: 5.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>