KIR2DL4 [The Human Chemical-Genetic Interaction Map Project]

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======= KIR2DL4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KIR2DL4
  * **<color #00a2e8>Official Name</color>**: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3805|3805]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99706|Q99706]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KIR2DL4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KIR2DL4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ig|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MHC class Ib receptor activity|
|positive regulation of natural killer cell cytokine production|
|regulation of natural killer cell cytokine production|
|positive regulation of cellular senescence|
|negative regulation of natural killer cell mediated cytotoxicity|
|positive regulation of cell aging|
|negative regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated cytotoxicity|
|negative regulation of cell killing|
|positive regulation of natural killer cell mediated immunity|
|negative regulation of lymphocyte mediated immunity|
|regulation of cellular senescence|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|regulation of cell aging|
|negative regulation of leukocyte mediated immunity|
|cellular defense response|
|positive regulation of cytokine production involved in immune response|
|negative regulation of innate immune response|
|regulation of leukocyte mediated cytotoxicity|
|regulation of cytokine production involved in immune response|
|negative regulation of response to biotic stimulus|
|positive regulation of production of molecular mediator of immune response|
|regulation of cell killing|
|positive regulation of lymphocyte mediated immunity|
|negative regulation of immune effector process|
|positive regulation of leukocyte mediated immunity|
|transmembrane signaling receptor activity|
|regulation of production of molecular mediator of immune response|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|early endosome membrane|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|positive regulation of immune effector process|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|negative regulation of response to external stimulus|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|positive regulation of response to external stimulus|
|regulation of cytokine production|
|regulation of cellular response to stress|
|regulation of defense response|
|regulation of multi-organism process|
|positive regulation of immune response|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.07|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.79|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.77|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|1.81|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.05|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14044
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KIR2DL4 Expression in NALM6 Cells: 3.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>