KLHL31 [The Human Chemical-Genetic Interaction Map Project]

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======= KLHL31 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KLHL31
  * **<color #00a2e8>Official Name</color>**: kelch like family member 31
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=401265|401265]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H511|Q9H511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KLHL31&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KLHL31|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610749|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor in MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). {ECO:0000269|PubMed:18719355}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Kelch 1|
|BTB|
|BACK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of JNK cascade|
|negative regulation of stress-activated protein kinase signaling cascade|
|negative regulation of stress-activated MAPK cascade|
|negative regulation of MAPK cascade|
|regulation of JNK cascade|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|negative regulation of protein phosphorylation|
|negative regulation of phosphorylation|
|negative regulation of intracellular signal transduction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of protein modification process|
|regulation of cellular response to stress|
|regulation of MAPK cascade|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of phosphorylation|
|negative regulation of response to stimulus|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|-1.91|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.73|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.7|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|1.7|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.71|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.71|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.72|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.75|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.88|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.9|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|2.08|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.09|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.26|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.36|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15953
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.38 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KLHL31 Expression in NALM6 Cells: -2.38'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>