KMO [The Human Chemical-Genetic Interaction Map Project]

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======= KMO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KMO
  * **<color #00a2e8>Official Name</color>**: kynurenine 3-monooxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8564|8564]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15229|O15229]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KMO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KMO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603538|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|kynurenine 3-monooxygenase activity|
|kynurenic acid biosynthetic process|
|kynurenic acid metabolic process|
|regulation of glutamate secretion, neurotransmission|
|anthranilate metabolic process|
|positive regulation of glutamate secretion, neurotransmission|
|quinolinate biosynthetic process|
|quinolinate metabolic process|
|de novo NAD biosynthetic process from tryptophan|
|de novo NAD biosynthetic process|
|L-kynurenine metabolic process|
|NAD(P)H oxidase activity|
|tryptophan catabolic process|
|indole-containing compound catabolic process|
|positive regulation of glutamate secretion|
|indolalkylamine catabolic process|
|kynurenine metabolic process|
|tryptophan metabolic process|
|dicarboxylic acid biosynthetic process|
|regulation of glutamate secretion|
|indolalkylamine metabolic process|
|positive regulation of amino acid transport|
|cellular biogenic amine catabolic process|
|amine catabolic process|
|positive regulation of neurotransmitter secretion|
|response to salt stress|
|indole-containing compound metabolic process|
|benzene-containing compound metabolic process|
|aromatic amino acid family catabolic process|
|NAD biosynthetic process|
|regulation of amino acid transport|
|positive regulation of synaptic transmission, glutamatergic|
|nicotinamide nucleotide biosynthetic process|
|pyridine nucleotide biosynthetic process|
|nicotinamide nucleotide metabolic process|
|FAD binding|
|pyridine nucleotide metabolic process|
|positive regulation of organic acid transport|
|positive regulation of amine transport|
|pyridine-containing compound biosynthetic process|
|positive regulation of neurotransmitter transport|
|aromatic amino acid family metabolic process|
|pyridine-containing compound metabolic process|
|NAD metabolic process|
|oxidoreduction coenzyme metabolic process|
|positive regulation of anion transport|
|cellular biogenic amine metabolic process|
|cellular amine metabolic process|
|flavin adenine dinucleotide binding|
|regulation of organic acid transport|
|amine metabolic process|
|regulation of synaptic transmission, glutamatergic|
|cellular ketone metabolic process|
|response to osmotic stress|
|water-soluble vitamin metabolic process|
|positive regulation of neuron death|
|regulation of amine transport|
|regulation of anion transport|
|dicarboxylic acid metabolic process|
|regulation of neurotransmitter secretion|
|alpha-amino acid catabolic process|
|vitamin metabolic process|
|cellular amino acid catabolic process|
|coenzyme biosynthetic process|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|mitochondrial outer membrane|
|cellular response to interleukin-1|
|cellular response to lipopolysaccharide|
|monocarboxylic acid biosynthetic process|
|cellular response to molecule of bacterial origin|
|response to interleukin-1|
|alpha-amino acid metabolic process|
|cofactor biosynthetic process|
|cellular response to biotic stimulus|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|positive regulation of ion transport|
|aging|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|regulation of neuron death|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of neurotransmitter levels|
|positive regulation of secretion by cell|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|positive regulation of secretion|
|small molecule catabolic process|
|cofactor metabolic process|
|modulation of chemical synaptic transmission|
|aromatic compound catabolic process|
|regulation of trans-synaptic signaling|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic cyclic compound catabolic process|
|drug metabolic process|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|response to bacterium|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of secretion by cell|
|regulation of secretion|
|response to lipid|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|regulation of cellular localization|
|oxidation-reduction process|
|positive regulation of transport|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.438|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14468
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KMO Expression in NALM6 Cells: 3.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>