KNTC1 [The Human Chemical-Genetic Interaction Map Project]

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======= KNTC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KNTC1
  * **<color #00a2e8>Official Name</color>**: kinetochore associated 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9735|9735]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50748|P50748]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KNTC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KNTC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607363|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. Experimental evidence indicated that the encoded protein functioned in a similar manner to that of the Drosophila rough deal protein. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex. {ECO:0000269|PubMed:11146660, ECO:0000269|PubMed:11590237, ECO:0000269|PubMed:15824131, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rod C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RZZ complex|
|kinetochore microtubule|
|regulation of exit from mitosis|
|condensed chromosome kinetochore|
|spindle pole|
|mitotic cell cycle checkpoint|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|cell cycle checkpoint|
|actin cytoskeleton|
|negative regulation of mitotic cell cycle|
|regulation of mitotic cell cycle phase transition|
|regulation of cell cycle phase transition|
|cell division|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|regulation of cell cycle process|
|cell cycle process|
|regulation of cell cycle|
|regulation of organelle organization|
|cell cycle|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-4.42|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-3.8|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-3.59|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-3.4|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-3.31|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-2.96|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.92|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.92|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.61|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.48|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.44|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.41|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-2.38|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.24|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.22|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.15|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.04|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-2.02|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.99|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-1.99|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.95|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.92|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|-1.85|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.8|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.76|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|-1.75|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-1.71|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.9|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|5.88|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|6.55|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|6.56|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|6.64|
|[[:results:exp17|DABN 20μM R00 exp17]]|6.66|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|7.45|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|7.6|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|8.1|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|8.27|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|8.27|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|8.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:zw10|ZW10]]|0.871|
|[[:human genes:t:trip13|TRIP13]]|0.828|
|[[:human genes:m:mad2l1|MAD2L1]]|0.803|
|[[:human genes:b:bub1b|BUB1B]]|0.797|
|[[:human genes:z:zwilch|ZWILCH]]|0.793|
|[[:human genes:m:mad1l1|MAD1L1]]|0.778|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.759|
|[[:human genes:r:rbm14|RBM14]]|0.746|
|[[:human genes:b:bub3|BUB3]]|0.72|
|[[:human genes:c:cdc20|CDC20]]|0.601|
|[[:human genes:f:fnta|FNTA]]|0.534|
|[[:human genes:f:fntb|FNTB]]|0.512|
|[[:human genes:c:ccnb1|CCNB1]]|0.471|
|[[:human genes:p:pelo|PELO]]|0.446|
|[[:human genes:b:bub1|BUB1]]|0.442|
|[[:human genes:c:cenpe|CENPE]]|0.438|
|[[:human genes:d:ddx20|DDX20]]|0.437|
|[[:human genes:t:tgs1|TGS1]]|0.414|
|[[:human genes:t:tbca|TBCA]]|0.411|
|[[:human genes:t:tcf4|TCF4]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KNTC1 Expression in NALM6 Cells: 8.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>