KRT19 [The Human Chemical-Genetic Interaction Map Project]

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======= KRT19 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT19
  * **<color #00a2e8>Official Name</color>**: keratin 19
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3880|3880]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08727|P08727]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT19&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT19|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/148020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|terminal web|
|dystrophin-associated glycoprotein complex|
|apicolateral plasma membrane|
|costamere|
|cell differentiation involved in embryonic placenta development|
|cell periphery|
|sarcomere organization|
|structural constituent of muscle|
|myofibril assembly|
|response to estrogen|
|embryonic placenta development|
|sarcolemma|
|structural constituent of cytoskeleton|
|cellular component assembly involved in morphogenesis|
|cornification|
|actomyosin structure organization|
|intermediate filament|
|Notch signaling pathway|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|placenta development|
|striated muscle cell differentiation|
|keratinization|
|muscle cell differentiation|
|protein-containing complex binding|
|keratinocyte differentiation|
|epidermal cell differentiation|
|in utero embryonic development|
|skin development|
|epidermis development|
|reproductive structure development|
|reproductive system development|
|embryonic organ development|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|viral process|
|organelle assembly|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|embryo development|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|epithelium development|
|reproductive process|
|reproduction|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.493|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12954
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT19 Expression in NALM6 Cells: -3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>