KRT1 [The Human Chemical-Genetic Interaction Map Project]

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======= KRT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT1
  * **<color #00a2e8>Official Name</color>**: keratin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3848|3848]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04264|P04264]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/139350|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. {ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21544310}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|complement activation, lectin pathway|
|structural constituent of epidermis|
|fibrinolysis|
|establishment of skin barrier|
|regulation of water loss via skin|
|protein heterotetramerization|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|peptide cross-linking|
|cornified envelope|
|multicellular organismal water homeostasis|
|negative regulation of wound healing|
|water homeostasis|
|retina homeostasis|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|keratin filament|
|protein heterooligomerization|
|cornification|
|ficolin-1-rich granule lumen|
|negative regulation of inflammatory response|
|regulation of wound healing|
|blood microparticle|
|protein tetramerization|
|regulation of response to wounding|
|carbohydrate binding|
|complement activation|
|tissue homeostasis|
|signaling receptor activity|
|negative regulation of defense response|
|keratinization|
|keratinocyte differentiation|
|regulation of angiogenesis|
|epidermal cell differentiation|
|regulation of vasculature development|
|multicellular organismal homeostasis|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|humoral immune response|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|cytoskeleton|
|skin development|
|response to oxidative stress|
|epidermis development|
|neutrophil degranulation|
|protein heterodimerization activity|
|neutrophil activation involved in immune response|
|regulation of body fluid levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|myeloid cell activation involved in immune response|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|epithelial cell differentiation|
|regulated exocytosis|
|regulation of defense response|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|export from cell|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|cell death|
|regulation of response to external stimulus|
|chemical homeostasis|
|epithelium development|
|secretion|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|protein-containing complex assembly|
|extracellular space|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|tissue development|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>