KRT2 [The Human Chemical-Genetic Interaction Map Project]

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======= KRT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KRT2
  * **<color #00a2e8>Official Name</color>**: keratin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3849|3849]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P35908|P35908]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KRT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KRT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization. {ECO:0000269|PubMed:12598329, ECO:0000269|PubMed:1380918}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Filament|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|keratinocyte activation|
|keratinocyte migration|
|keratinocyte proliferation|
|keratinocyte development|
|structural constituent of epidermis|
|intermediate filament organization|
|positive regulation of epidermis development|
|intermediate filament cytoskeleton organization|
|intermediate filament-based process|
|peptide cross-linking|
|cornified envelope|
|cytoskeletal protein binding|
|epithelial cell migration|
|regulation of epidermis development|
|epithelial cell proliferation|
|epithelium migration|
|tissue migration|
|keratin filament|
|structural constituent of cytoskeleton|
|cornification|
|intermediate filament|
|ameboidal-type cell migration|
|epithelial cell development|
|keratinization|
|keratinocyte differentiation|
|epidermal cell differentiation|
|skin development|
|epidermis development|
|supramolecular fiber organization|
|cell population proliferation|
|epithelial cell differentiation|
|cell migration|
|programmed cell death|
|cell activation|
|cell motility|
|localization of cell|
|cell death|
|cytoskeleton organization|
|epithelium development|
|locomotion|
|positive regulation of developmental process|
|movement of cell or subcellular component|
|extracellular space|
|cell development|
|tissue development|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-2|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rps12|RPS12]]|0.497|
|[[:human genes:r:rrp7a|RRP7A]]|0.467|
|[[:human genes:x:xab2|XAB2]]|0.462|
|[[:human genes:p:psmd14|PSMD14]]|0.461|
|[[:human genes:d:ddt|DDT]]|0.458|
|[[:human genes:t:twistnb|TWISTNB]]|0.455|
|[[:human genes:p:pan3|PAN3]]|0.447|
|[[:human genes:o:orc1|ORC1]]|0.441|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.435|
|[[:human genes:b:brd2|BRD2]]|0.434|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.434|
|[[:human genes:n:nop16|NOP16]]|0.433|
|[[:human genes:g:golga8o|GOLGA8O]]|0.43|
|[[:human genes:p:psmb2|PSMB2]]|0.43|
|[[:human genes:s:slc6a17|SLC6A17]]|0.429|
|[[:human genes:r:rps2|RPS2]]|0.428|
|[[:human genes:k:krt78|KRT78]]|0.424|
|[[:human genes:p:psmd2|PSMD2]]|0.423|
|[[:human genes:u:upf1|UPF1]]|0.423|
|[[:human genes:t:trappc11|TRAPPC11]]|0.422|
|[[:human genes:a:ankle1|ANKLE1]]|0.422|
|[[:human genes:r:rps7|RPS7]]|0.422|
|[[:human genes:c:chd4|CHD4]]|0.421|
|[[:human genes:p:polr2d|POLR2D]]|0.42|
|[[:human genes:c:cbwd3|CBWD3]]|0.42|
|[[:human genes:p:psmb1|PSMB1]]|0.419|
|[[:human genes:n:nol10|NOL10]]|0.417|
|[[:human genes:p:psmb4|PSMB4]]|0.416|
|[[:human genes:a:aamp|AAMP]]|0.415|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.414|
|[[:human genes:s:supt6h|SUPT6H]]|0.414|
|[[:human genes:r:rps5|RPS5]]|0.414|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.413|
|[[:human genes:p:plk1|PLK1]]|0.413|
|[[:human genes:c:cbwd5|CBWD5]]|0.412|
|[[:human genes:d:ddtl|DDTL]]|0.411|
|[[:human genes:b:brf2|BRF2]]|0.41|
|[[:human genes:s:supt5h|SUPT5H]]|0.406|
|[[:human genes:s:smg1|SMG1]]|0.404|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.402|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.401|
|[[:human genes:p:pola2|POLA2]]|0.401|
|[[:human genes:p:polr2f|POLR2F]]|0.4|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2247
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KRT2 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>