KTI12 [The Human Chemical-Genetic Interaction Map Project]

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======= KTI12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: KTI12
  * **<color #00a2e8>Official Name</color>**: KTI12 chromatin associated homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=112970|112970]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EK9|Q96EK9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=KTI12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20KTI12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|KTI12|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Elongator holoenzyme complex|
|tRNA wobble uridine modification|
|tRNA wobble base modification|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|ATP binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.07|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.76|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.73|
|[[:results:exp504|MK2206 4μM R08 exp504]]|1.7|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.77|
|[[:results:exp274|Citral 50μM R06 exp274]]|1.86|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.9|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.9|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.09|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.09|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|2.12|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|2.15|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.22|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.25|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.27|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|2.4|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.49|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.62|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.79|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.18|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|3.55|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:e:elp6|ELP6]]|0.773|
|[[:human genes:c:ctu1|CTU1]]|0.733|
|[[:human genes:e:elp2|ELP2]]|0.682|
|[[:human genes:e:elp3|ELP3]]|0.681|
|[[:human genes:n:nr2c2ap|NR2C2AP]]|0.651|
|[[:human genes:u:urm1|URM1]]|0.651|
|[[:human genes:c:ctu2|CTU2]]|0.65|
|[[:human genes:m:mocs3|MOCS3]]|0.629|
|[[:human genes:d:dph3|DPH3]]|0.629|
|[[:human genes:e:elp5|ELP5]]|0.606|
|[[:human genes:i:ikbkap|IKBKAP]]|0.529|
|[[:human genes:f:fam98b|FAM98B]]|0.52|
|[[:human genes:e:elp4|ELP4]]|0.519|
|[[:human genes:a:alkbh8|ALKBH8]]|0.462|
|[[:human genes:s:slc7a1|SLC7A1]]|0.455|
|[[:human genes:d:dph1|DPH1]]|0.45|
|[[:human genes:p:pmvk|PMVK]]|0.443|
|[[:human genes:d:dph5|DPH5]]|0.437|
|[[:human genes:d:ddx1|DDX1]]|0.408|
|[[:human genes:w:wdr83|WDR83]]|0.405|
|[[:human genes:c:c16orf80|C16orf80]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 432/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|15/28|
|blood|11/28|
|bone|13/25|
|breast|14/33|
|central nervous system|38/56|
|cervix|1/4|
|colorectal|11/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|7/15|
|kidney|15/21|
|liver|14/20|
|lung|47/75|
|lymphocyte|5/14|
|ovary|16/26|
|pancreas|16/24|
|peripheral nervous system|9/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|19/24|
|soft tissue|4/7|
|thyroid|2/2|
|upper aerodigestive|19/22|
|urinary tract|20/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='KTI12 Expression in NALM6 Cells: 4.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>