L3MBTL2 [The Human Chemical-Genetic Interaction Map Project]

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======= L3MBTL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: L3MBTL2
  * **<color #00a2e8>Official Name</color>**: L3MBTL histone methyl-lysine binding protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=83746|83746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q969R5|Q969R5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=L3MBTL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20L3MBTL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611865|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. {ECO:0000269|PubMed:19233876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MBT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of G0 to G1 transition|
|regulation of G0 to G1 transition|
|methylated histone binding|
|histone binding|
|negative regulation of cell cycle process|
|negative regulation of cell cycle|
|chromatin organization|
|regulation of cell cycle process|
|zinc ion binding|
|chromosome organization|
|regulation of cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2.71|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.94|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.91|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.89|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.71|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3147
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='L3MBTL2 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>