LAD1 [The Human Chemical-Genetic Interaction Map Project]

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======= LAD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAD1
  * **<color #00a2e8>Official Name</color>**: ladinin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3898|3898]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00515|O00515]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602314|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Anchoring filament protein which is a component of the basement membrane zone. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|basement membrane|
|structural molecule activity|
|actin cytoskeleton|
|cadherin binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.86|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.81|
|[[:results:exp340|BN82002 4μM R07 exp340]]|1.7|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|1.77|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.78|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.546|
|[[:human genes:c:cbwd5|CBWD5]]|0.528|
|[[:human genes:c:chd4|CHD4]]|0.52|
|[[:human genes:c:cbwd3|CBWD3]]|0.519|
|[[:human genes:d:ddtl|DDTL]]|0.51|
|[[:human genes:r:rpl35|RPL35]]|0.503|
|[[:human genes:p:polr2j3|POLR2J3]]|0.489|
|[[:human genes:z:zfand5|ZFAND5]]|0.488|
|[[:human genes:l:lrr1|LRR1]]|0.478|
|[[:human genes:c:cbwd6|CBWD6]]|0.474|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.473|
|[[:human genes:p:psmc6|PSMC6]]|0.472|
|[[:human genes:r:rrp7a|RRP7A]]|0.472|
|[[:human genes:n:nbpf16|NBPF16]]|0.468|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.467|
|[[:human genes:p:psmd6|PSMD6]]|0.464|
|[[:human genes:s:ssh2|SSH2]]|0.462|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.461|
|[[:human genes:p:pole|POLE]]|0.459|
|[[:human genes:c:c14orf93|C14orf93]]|0.457|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.456|
|[[:human genes:c:ccna2|CCNA2]]|0.456|
|[[:human genes:p:pola1|POLA1]]|0.455|
|[[:human genes:p:psmd2|PSMD2]]|0.454|
|[[:human genes:s:supt6h|SUPT6H]]|0.454|
|[[:human genes:k:kctd17|KCTD17]]|0.452|
|[[:human genes:s:stil|STIL]]|0.452|
|[[:human genes:p:pwp2|PWP2]]|0.451|
|[[:human genes:c:chchd3|CHCHD3]]|0.45|
|[[:human genes:n:npipb5|NPIPB5]]|0.45|
|[[:human genes:n:nup205|NUP205]]|0.45|
|[[:human genes:c:cactin|CACTIN]]|0.445|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.445|
|[[:human genes:t:tceb3c|TCEB3C]]|0.444|
|[[:human genes:p:psmb2|PSMB2]]|0.444|
|[[:human genes:n:nup160|NUP160]]|0.443|
|[[:human genes:r:rps2|RPS2]]|0.442|
|[[:human genes:s:slc38a7|SLC38A7]]|0.442|
|[[:human genes:z:znf583|ZNF583]]|0.44|
|[[:human genes:p:psmd1|PSMD1]]|0.439|
|[[:human genes:r:ranbp2|RANBP2]]|0.439|
|[[:human genes:c:cope|COPE]]|0.437|
|[[:human genes:h:hivep3|HIVEP3]]|0.437|
|[[:human genes:s:snrpa1|SNRPA1]]|0.437|
|[[:human genes:p:prim1|PRIM1]]|0.436|
|[[:human genes:m:myb|MYB]]|0.436|
|[[:human genes:c:copg1|COPG1]]|0.435|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.434|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.434|
|[[:human genes:n:nup133|NUP133]]|0.434|
|[[:human genes:s:sart1|SART1]]|0.43|
|[[:human genes:a:ankle2|ANKLE2]]|0.43|
|[[:human genes:n:nol9|NOL9]]|0.429|
|[[:human genes:h:hap1|HAP1]]|0.428|
|[[:human genes:p:psma6|PSMA6]]|0.428|
|[[:human genes:s:slc6a17|SLC6A17]]|0.428|
|[[:human genes:a:aamp|AAMP]]|0.427|
|[[:human genes:n:npipb11|NPIPB11]]|0.426|
|[[:human genes:c:ccdc94|CCDC94]]|0.426|
|[[:human genes:u:upf1|UPF1]]|0.426|
|[[:human genes:d:ddx56|DDX56]]|0.426|
|[[:human genes:m:med17|MED17]]|0.425|
|[[:human genes:p:pan3|PAN3]]|0.425|
|[[:human genes:p:psmd3|PSMD3]]|0.425|
|[[:human genes:r:rad21|RAD21]]|0.424|
|[[:human genes:b:bage2|BAGE2]]|0.424|
|[[:human genes:b:bage|BAGE]]|0.424|
|[[:human genes:b:bage3|BAGE3]]|0.424|
|[[:human genes:b:bage4|BAGE4]]|0.423|
|[[:human genes:r:rps5|RPS5]]|0.423|
|[[:human genes:s:sf3a1|SF3A1]]|0.423|
|[[:human genes:v:vasn|VASN]]|0.423|
|[[:human genes:b:bage5|BAGE5]]|0.423|
|[[:human genes:i:ik|IK]]|0.423|
|[[:human genes:s:supt5h|SUPT5H]]|0.422|
|[[:human genes:m:mdm2|MDM2]]|0.422|
|[[:human genes:p:pde4dip|PDE4DIP]]|0.421|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.421|
|[[:human genes:p:psmd14|PSMD14]]|0.42|
|[[:human genes:k:kpnb1|KPNB1]]|0.42|
|[[:human genes:p:psma7|PSMA7]]|0.42|
|[[:human genes:r:rnpc3|RNPC3]]|0.419|
|[[:human genes:r:rpl6|RPL6]]|0.419|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.418|
|[[:human genes:f:fbxw9|FBXW9]]|0.418|
|[[:human genes:r:rps9|RPS9]]|0.418|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.418|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.418|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.417|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.417|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.417|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.417|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.417|
|[[:human genes:p:psmc1|PSMC1]]|0.416|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.416|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.416|
|[[:human genes:p:psmc2|PSMC2]]|0.416|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.416|
|[[:human genes:s:smg1|SMG1]]|0.415|
|[[:human genes:a:atp13a1|ATP13A1]]|0.415|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.414|
|[[:human genes:c:cwc22|CWC22]]|0.414|
|[[:human genes:p:psmd11|PSMD11]]|0.414|
|[[:human genes:m:mt1e|MT1E]]|0.413|
|[[:human genes:r:rps7|RPS7]]|0.413|
|[[:human genes:c:col2a1|COL2A1]]|0.413|
|[[:human genes:c:ckap5|CKAP5]]|0.412|
|[[:human genes:p:pbxip1|PBXIP1]]|0.412|
|[[:human genes:a:arcn1|ARCN1]]|0.412|
|[[:human genes:m:madcam1|MADCAM1]]|0.411|
|[[:human genes:c:cdc45|CDC45]]|0.411|
|[[:human genes:r:rbm39|RBM39]]|0.411|
|[[:human genes:s:sec13|SEC13]]|0.411|
|[[:human genes:n:ndc80|NDC80]]|0.41|
|[[:human genes:m:myt1l|MYT1L]]|0.41|
|[[:human genes:c:cdca3|CDCA3]]|0.409|
|[[:human genes:p:psmb1|PSMB1]]|0.409|
|[[:human genes:u:uqcrh|UQCRH]]|0.408|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.408|
|[[:human genes:t:tspy1|TSPY1]]|0.407|
|[[:human genes:p:pan2|PAN2]]|0.407|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.406|
|[[:human genes:h:heatr1|HEATR1]]|0.405|
|[[:human genes:s:slc4a1|SLC4A1]]|0.405|
|[[:human genes:p:ppfia4|PPFIA4]]|0.404|
|[[:human genes:n:nup85|NUP85]]|0.404|
|[[:human genes:r:rbbp5|RBBP5]]|0.404|
|[[:human genes:w:wdr43|WDR43]]|0.403|
|[[:human genes:t:tpx2|TPX2]]|0.403|
|[[:human genes:w:wdr75|WDR75]]|0.403|
|[[:human genes:f:fam231c|FAM231C]]|0.401|
|[[:human genes:r:rpl38|RPL38]]|0.401|
|[[:human genes:f:fam231a|FAM231A]]|0.401|
|[[:human genes:z:znf106|ZNF106]]|0.4|
|[[:human genes:e:exosc6|EXOSC6]]|0.4|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.4|
|[[:human genes:s:smg7|SMG7]]|0.4|
|[[:human genes:o:orc6|ORC6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1793
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAD1 Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>