LAMA1 [The Human Chemical-Genetic Interaction Map Project]

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======= LAMA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAMA1
  * **<color #00a2e8>Official Name</color>**: laminin subunit alpha 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284217|284217]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25391|P25391]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAMA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAMA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150320|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes one of the alpha 1 subunits of laminin. The laminins are a family of extracellular matrix glycoproteins that have a heterotrimeric structure consisting of an alpha, beta and gamma chain. These proteins make up a major component of the basement membrane and have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Mutations in this gene may be associated with Poretti-Boltshauser syndrome. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin I|
|Laminin G 1|
|Laminin II|
|Laminin N|
|Laminin G 2|
|Laminin B|
|Laminin EGF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|laminin-3 complex|
|laminin-1 complex|
|glycosphingolipid binding|
|retinal blood vessel morphogenesis|
|retina vasculature morphogenesis in camera-type eye|
|establishment of epithelial cell apical/basal polarity|
|retina vasculature development in camera-type eye|
|branching involved in salivary gland morphogenesis|
|polarized epithelial cell differentiation|
|establishment of apical/basal cell polarity|
|establishment of monopolar cell polarity|
|establishment or maintenance of monopolar cell polarity|
|epithelial tube branching involved in lung morphogenesis|
|salivary gland morphogenesis|
|establishment of epithelial cell polarity|
|salivary gland development|
|exocrine system development|
|morphogenesis of a polarized epithelium|
|lung morphogenesis|
|establishment or maintenance of epithelial cell apical/basal polarity|
|morphogenesis of an epithelial sheet|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|basement membrane|
|gland morphogenesis|
|establishment of cell polarity|
|regulation of embryonic development|
|branching morphogenesis of an epithelial tube|
|extracellular matrix structural constituent|
|retina development in camera-type eye|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|lung development|
|cell-cell junction|
|respiratory tube development|
|protein C-terminus binding|
|respiratory system development|
|establishment or maintenance of cell polarity|
|extracellular matrix|
|axon guidance|
|neuron projection guidance|
|epithelial tube morphogenesis|
|camera-type eye development|
|signaling receptor binding|
|extracellular matrix organization|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|axonogenesis|
|extracellular structure organization|
|blood vessel morphogenesis|
|axon development|
|gland development|
|morphogenesis of an epithelium|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|cell projection morphogenesis|
|vasculature development|
|cell part morphogenesis|
|cardiovascular system development|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|tube morphogenesis|
|neuron projection development|
|epithelial cell differentiation|
|regulation of cell adhesion|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|regulation of cell motility|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|protein phosphorylation|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|locomotion|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|neurogenesis|
|cell development|
|tissue development|
|extracellular region|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11669
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAMA1 Expression in NALM6 Cells: 2.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>