LAPTM4B [The Human Chemical-Genetic Interaction Map Project]

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======= LAPTM4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAPTM4B
  * **<color #00a2e8>Official Name</color>**: lysosomal protein transmembrane 4 beta
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55353|55353]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VI4|Q86VI4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAPTM4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAPTM4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613296|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25588945, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:26126825, ECO:0000269|PubMed:26280656}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mtp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of lysosomal membrane permeability|
|lysosomal membrane organization|
|multivesicular body, internal vesicle|
|negative regulation of protein catabolic process in the vacuole|
|negative regulation of lysosomal protein catabolic process|
|regulation of lysosome organization|
|phosphatidylinositol bisphosphate binding|
|ceramide binding|
|negative regulation of transforming growth factor beta1 production|
|regulation of lysosomal protein catabolic process|
|negative regulation of transforming growth factor beta production|
|regulation of protein catabolic process in the vacuole|
|regulation of transforming growth factor beta1 production|
|multivesicular body membrane|
|endosome transport via multivesicular body sorting pathway|
|multivesicular body sorting pathway|
|regulation of transforming growth factor beta production|
|regulation of vacuole organization|
|lysosome organization|
|lytic vacuole organization|
|endosome organization|
|regulation of membrane permeability|
|negative regulation of cellular protein catabolic process|
|kinase binding|
|cell projection|
|late endosome membrane|
|vacuole organization|
|negative regulation of protein catabolic process|
|endosomal transport|
|regulation of cellular protein catabolic process|
|lysosome|
|negative regulation of cellular catabolic process|
|early endosome|
|endosome|
|negative regulation of cytokine production|
|ubiquitin protein ligase binding|
|vesicle organization|
|lysosomal membrane|
|negative regulation of catabolic process|
|regulation of protein catabolic process|
|endomembrane system organization|
|regulation of cytokine production|
|regulation of cellular catabolic process|
|membrane organization|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|regulation of organelle organization|
|intracellular transport|
|establishment of localization in cell|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.92|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12590
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAPTM4B Expression in NALM6 Cells: 5.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>