LARP6 [The Human Chemical-Genetic Interaction Map Project]

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======= LARP6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LARP6
  * **<color #00a2e8>Official Name</color>**: La ribonucleoprotein 6, translational regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55323|55323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRS8|Q9BRS8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LARP6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LARP6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9. {ECO:0000269|PubMed:20603131, ECO:0000269|PubMed:21746880, ECO:0000269|PubMed:22190748}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SUZ-C|
|La|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of mRNA binding|
|positive regulation of RNA binding|
|regulation of mRNA binding|
|sequence-specific mRNA binding|
|regulation of RNA binding|
|RNA stem-loop binding|
|myosin binding|
|mRNA 5-UTR binding|
|positive regulation of collagen biosynthetic process|
|positive regulation of collagen metabolic process|
|regulation of collagen biosynthetic process|
|regulation of collagen metabolic process|
|polysome|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|ribonucleoprotein complex|
|positive regulation of binding|
|regulation of translation|
|regulation of binding|
|regulation of cellular amide metabolic process|
|posttranscriptional regulation of gene expression|
|RNA processing|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.9|
|[[:results:exp303|39°C R06 exp303]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13069
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LARP6 Expression in NALM6 Cells: 1.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>