LAT [The Human Chemical-Genetic Interaction Map Project]

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======= LAT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LAT
  * **<color #00a2e8>Official Name</color>**: linker for activation of T cells
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27040|27040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43561|O43561]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LAT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LAT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602354|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for TCR (T-cell antigen receptor)- and pre-TCR- mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. {ECO:0000269|PubMed:10072481}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mast cell degranulation|
|mast cell activation involved in immune response|
|mast cell mediated immunity|
|mast cell granule|
|mast cell activation|
|COP9 signalosome|
|immunological synapse|
|lysosome localization|
|lymphocyte homeostasis|
|SH3/SH2 adaptor activity|
|leukocyte homeostasis|
|integrin-mediated signaling pathway|
|calcium-mediated signaling|
|cell-cell junction|
|Fc-epsilon receptor signaling pathway|
|T cell receptor signaling pathway|
|homeostasis of number of cells|
|membrane raft|
|T cell activation|
|Fc receptor signaling pathway|
|Ras protein signal transduction|
|antigen receptor-mediated signaling pathway|
|regulation of T cell activation|
|small GTPase mediated signal transduction|
|second-messenger-mediated signaling|
|establishment of organelle localization|
|MAPK cascade|
|lymphocyte activation|
|signal transduction by protein phosphorylation|
|immune response-activating cell surface receptor signaling pathway|
|protein kinase binding|
|immune response-regulating cell surface receptor signaling pathway|
|inflammatory response|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|organelle localization|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of transferase activity|
|regulated exocytosis|
|leukocyte mediated immunity|
|exocytosis|
|regulation of protein kinase activity|
|positive regulation of immune response|
|regulation of kinase activity|
|leukocyte activation|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|secretion by cell|
|positive regulation of protein phosphorylation|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|phosphorylation|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|intracellular transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.97|
|[[:results:exp300|VE-822 0.04μM R06 exp300]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LAT Expression in NALM6 Cells: 3.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>