LBP [The Human Chemical-Genetic Interaction Map Project]

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======= LBP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LBP
  * **<color #00a2e8>Official Name</color>**: lipopolysaccharide binding protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3929|3929]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P18428|P18428]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LBP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LBP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/151990|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359). {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:24120359, ECO:0000269|PubMed:7517398, ECO:0000305|PubMed:17481951}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LBP BPI CETP|
|LBP BPI CETP C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|lipopolysaccharide transport|
|positive regulation of respiratory burst involved in inflammatory response|
|lipoteichoic acid binding|
|leukocyte chemotaxis involved in inflammatory response|
|regulation of respiratory burst involved in inflammatory response|
|opsonization|
|positive regulation of toll-like receptor 4 signaling pathway|
|lipopeptide binding|
|positive regulation of respiratory burst|
|response to lipoteichoic acid|
|cellular response to lipoteichoic acid|
|positive regulation of cytolysis|
|detection of molecule of bacterial origin|
|macrophage activation involved in immune response|
|leukocyte migration involved in inflammatory response|
|regulation of respiratory burst|
|regulation of cytolysis|
|detection of external biotic stimulus|
|toll-like receptor 4 signaling pathway|
|positive regulation of tumor necrosis factor biosynthetic process|
|regulation of toll-like receptor 4 signaling pathway|
|positive regulation of toll-like receptor signaling pathway|
|detection of biotic stimulus|
|positive regulation of neutrophil chemotaxis|
|positive regulation of macrophage activation|
|positive regulation of granulocyte chemotaxis|
|positive regulation of neutrophil migration|
|regulation of neutrophil chemotaxis|
|regulation of tumor necrosis factor biosynthetic process|
|lipopolysaccharide-mediated signaling pathway|
|lipopolysaccharide binding|
|regulation of neutrophil migration|
|acute-phase response|
|regulation of granulocyte chemotaxis|
|positive regulation of interleukin-8 production|
|macrophage activation|
|regulation of macrophage activation|
|cellular defense response|
|positive regulation of chemokine production|
|negative regulation of tumor necrosis factor production|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|acute inflammatory response|
|carbohydrate derivative transport|
|regulation of chemokine production|
|defense response to Gram-negative bacterium|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of leukocyte chemotaxis|
|defense response to Gram-positive bacterium|
|positive regulation of interleukin-6 production|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|regulation of leukocyte chemotaxis|
|pattern recognition receptor signaling pathway|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|leukocyte chemotaxis|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|cell chemotaxis|
|regulation of chemotaxis|
|cellular response to biotic stimulus|
|positive regulation of immune effector process|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|negative regulation of cytokine production|
|lipid transport|
|response to lipopolysaccharide|
|lipid localization|
|response to molecule of bacterial origin|
|phagocytosis|
|defense response to bacterium|
|signaling receptor binding|
|regulation of inflammatory response|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|leukocyte migration|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of cytokine production|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of defense response|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|detection of chemical stimulus|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of cell migration|
|response to lipid|
|positive regulation of immune response|
|regulation of cell motility|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|regulation of immune system process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LBP Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>