LCN2 [The Human Chemical-Genetic Interaction Map Project]

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======= LCN2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LCN2
  * **<color #00a2e8>Official Name</color>**: lipocalin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3934|3934]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80188|P80188]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LCN2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LCN2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600181|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lipocalin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enterobactin binding|
|siderophore transport|
|sequestering of iron ion|
|response to mycotoxin|
|iron coordination entity transport|
|sequestering of metal ion|
|response to herbicide|
|small molecule binding|
|signal transduction in absence of ligand|
|extrinsic apoptotic signaling pathway in absence of ligand|
|protein homotrimerization|
|protein trimerization|
|cellular iron ion homeostasis|
|specific granule lumen|
|cellular response to hydrogen peroxide|
|iron ion transport|
|iron ion homeostasis|
|extrinsic apoptotic signaling pathway|
|positive regulation of cold-induced thermogenesis|
|protease binding|
|cellular transition metal ion homeostasis|
|antimicrobial humoral response|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|transition metal ion transport|
|transition metal ion homeostasis|
|cellular response to reactive oxygen species|
|iron ion binding|
|regulation of cold-induced thermogenesis|
|maintenance of location|
|cellular response to interleukin-1|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|response to reactive oxygen species|
|response to interleukin-1|
|cellular response to toxic substance|
|cellular response to biotic stimulus|
|cellular response to nutrient levels|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|cellular response to extracellular stimulus|
|response to virus|
|apoptotic signaling pathway|
|response to antibiotic|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|cellular response to external stimulus|
|protein homooligomerization|
|humoral immune response|
|positive regulation of cell projection organization|
|response to oxidative stress|
|cellular response to drug|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|response to nutrient levels|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|response to toxic substance|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|protein complex oligomerization|
|cellular response to lipid|
|myeloid cell activation involved in immune response|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular metal ion homeostasis|
|myeloid leukocyte activation|
|leukocyte activation involved in immune response|
|metal ion homeostasis|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulated exocytosis|
|cation homeostasis|
|regulation of cell projection organization|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|innate immune response|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|cation transport|
|response to lipid|
|protein homodimerization activity|
|cellular homeostasis|
|apoptotic process|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|cellular response to cytokine stimulus|
|response to drug|
|export from cell|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|cell death|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|secretion|
|positive regulation of cellular component organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|ion transport|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|homeostatic process|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|protein-containing complex subunit organization|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6472
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LCN2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>