LCP1 [The Human Chemical-Genetic Interaction Map Project]

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======= LCP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LCP1
  * **<color #00a2e8>Official Name</color>**: lymphocyte cytosolic protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3936|3936]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P13796|P13796]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LCP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LCP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153430|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Actin-binding protein (PubMed:16636079, PubMed:17294403, PubMed:28493397). Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28 (PubMed:17294403). Modulates the cell surface expression of IL2RA/CD25 and CD69 (PubMed:17294403). {ECO:0000269|PubMed:16636079, ECO:0000269|PubMed:17294403, ECO:0000269|PubMed:28493397}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|actin filament network formation|
|actin filament bundle|
|positive regulation of podosome assembly|
|protein kinase A signaling|
|regulation of podosome assembly|
|wound healing, spreading of cells|
|epiboly involved in wound healing|
|epiboly|
|phagocytic cup|
|podosome|
|GTPase binding|
|interleukin-12-mediated signaling pathway|
|cellular response to interleukin-12|
|response to interleukin-12|
|morphogenesis of an epithelial sheet|
|actin filament bundle assembly|
|T cell activation involved in immune response|
|extracellular matrix disassembly|
|actin filament bundle organization|
|stress fiber|
|filopodium|
|animal organ regeneration|
|positive regulation of organelle assembly|
|actin filament|
|ruffle|
|ruffle membrane|
|lymphocyte activation involved in immune response|
|integrin binding|
|regeneration|
|actin filament binding|
|actin cytoskeleton|
|regulation of organelle assembly|
|regulation of intracellular protein transport|
|T cell activation|
|actin filament organization|
|positive regulation of protein complex assembly|
|actin binding|
|extracellular matrix organization|
|regulation of intracellular transport|
|lymphocyte activation|
|extracellular structure organization|
|cellular component disassembly|
|focal adhesion|
|morphogenesis of an epithelium|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|wound healing|
|actin cytoskeleton organization|
|positive regulation of cellular component biogenesis|
|regulation of cellular protein localization|
|cell junction|
|tissue morphogenesis|
|actin filament-based process|
|response to wounding|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cytokine-mediated signaling pathway|
|perinuclear region of cytoplasm|
|regulation of protein transport|
|calcium ion binding|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|leukocyte activation|
|regulation of cellular component biogenesis|
|cell migration|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|identical protein binding|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|response to cytokine|
|cytoskeleton organization|
|epithelium development|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|movement of cell or subcellular component|
|extracellular space|
|intracellular signal transduction|
|tissue development|
|regulation of transport|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.79|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|-1.76|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.72|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.81|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5283
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LCP1 Expression in NALM6 Cells: 9.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>