LDB3 [The Human Chemical-Genetic Interaction Map Project]

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======= LDB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LDB3
  * **<color #00a2e8>Official Name</color>**: LIM domain binding 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11155|11155]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75112|O75112]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LDB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LDB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605906|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|PDZ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pseudopodium|
|muscle alpha-actinin binding|
|filamentous actin|
|sarcomere organization|
|protein kinase C binding|
|myofibril assembly|
|stress fiber|
|cytoskeletal protein binding|
|cellular component assembly involved in morphogenesis|
|cell-cell adherens junction|
|actomyosin structure organization|
|Z disc|
|striated muscle cell development|
|muscle cell development|
|striated muscle cell differentiation|
|muscle cell differentiation|
|actin binding|
|cytoskeleton|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|heart development|
|actin filament-based process|
|perinuclear region of cytoplasm|
|organelle assembly|
|cellular component morphogenesis|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cytoskeleton organization|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.92|
|[[:results:exp285|GW501516 25μM R06 exp285]]|1.75|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.8|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.42|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|2.46|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8824
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LDB3 Expression in NALM6 Cells: 2.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>