LDHB [The Human Chemical-Genetic Interaction Map Project]

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======= LDHB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LDHB
  * **<color #00a2e8>Official Name</color>**: lactate dehydrogenase B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3945|3945]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07195|P07195]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LDHB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LDHB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/150100|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ldh 1 N|
|Ldh 1 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-lactate dehydrogenase activity|
|lactate metabolic process|
|NAD binding|
|NAD metabolic process|
|pyruvate metabolic process|
|kinase binding|
|membrane raft|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|identical protein binding|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-2.93|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.29|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.9|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.88|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.83|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.8|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.77|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9413
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LDHB Expression in NALM6 Cells: 9.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>