LDOC1 [The Human Chemical-Genetic Interaction Map Project]

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======= LDOC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LDOC1
  * **<color #00a2e8>Official Name</color>**: LDOC1 regulator of NFKB signaling
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23641|23641]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95751|O95751]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LDOC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LDOC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300402|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May have an important role in the development and/or progression of some cancers.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of growth hormone activity|
|maternal process involved in parturition|
|cellular response to muramyl dipeptide|
|parturition|
|response to muramyl dipeptide|
|regulation of receptor binding|
|maternal placenta development|
|maternal process involved in female pregnancy|
|placenta development|
|regulation of signaling receptor activity|
|female pregnancy|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|multi-multicellular organism process|
|cellular response to biotic stimulus|
|regulation of protein binding|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|cellular response to peptide|
|regulation of binding|
|cellular response to drug|
|reproductive structure development|
|reproductive system development|
|response to peptide|
|cellular response to lipid|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|response to bacterium|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|response to lipid|
|nucleolus|
|multi-organism reproductive process|
|response to organonitrogen compound|
|response to drug|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cellular response to endogenous stimulus|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13038
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LDOC1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>