LENG8 [The Human Chemical-Genetic Interaction Map Project]

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======= LENG8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LENG8
  * **<color #00a2e8>Official Name</color>**: leukocyte receptor cluster member 8
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114823|114823]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96PV6|Q96PV6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LENG8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LENG8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616575|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAC3 GANP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-2.23|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.04|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.9|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.77|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 58/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|6/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|2/20|
|lung|8/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|3/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|1/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1697
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LENG8 Expression in NALM6 Cells: 7.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>