LEPROT [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= LEPROT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LEPROT
  * **<color #00a2e8>Official Name</color>**: leptin receptor overlapping transcript
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54741|54741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15243|O15243]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LEPROT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LEPROT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613461|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps55|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of growth hormone receptor signaling pathway|
|regulation of growth hormone receptor signaling pathway|
|late endosome to vacuole transport via multivesicular body sorting pathway|
|negative regulation of protein localization to cell surface|
|late endosome to vacuole transport|
|negative regulation of receptor signaling pathway via JAK-STAT|
|negative regulation of receptor signaling pathway via STAT|
|endosome transport via multivesicular body sorting pathway|
|positive regulation of protein targeting to mitochondrion|
|multivesicular body sorting pathway|
|regulation of protein localization to cell surface|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|negative regulation of cellular protein localization|
|positive regulation of mitochondrion organization|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|vacuolar transport|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|endosome membrane|
|endosomal transport|
|regulation of intracellular protein transport|
|endosome|
|positive regulation of cellular protein localization|
|signaling receptor binding|
|regulation of intracellular transport|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|intracellular transport|
|negative regulation of response to stimulus|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16336
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LEPROT Expression in NALM6 Cells: 5.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>