LFNG [The Human Chemical-Genetic Interaction Map Project]

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======= LFNG =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LFNG
  * **<color #00a2e8>Official Name</color>**: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3955|3955]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NES3|Q8NES3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LFNG&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LFNG|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602576|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the fringe gene family which also includes radical and manic fringe genes. They all encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). {ECO:0000250|UniProtKB:O09010, ECO:0000269|PubMed:11346656}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fringe|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of Notch signaling pathway involved in somitogenesis|
|regulation of Notch signaling pathway involved in somitogenesis|
|O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity|
|compartment pattern specification|
|protein O-linked fucosylation|
|regulation of somitogenesis|
|marginal zone B cell differentiation|
|mature B cell differentiation involved in immune response|
|fucosylation|
|acetylglucosaminyltransferase activity|
|positive regulation of meiotic cell cycle|
|mature B cell differentiation|
|negative regulation of embryonic development|
|negative regulation of Notch signaling pathway|
|B cell activation involved in immune response|
|regulation of meiotic cell cycle|
|ovarian follicle development|
|positive regulation of Notch signaling pathway|
|extracellular vesicle|
|integral component of Golgi membrane|
|somitogenesis|
|positive regulation of reproductive process|
|somite development|
|female gonad development|
|development of primary female sexual characteristics|
|positive regulation of protein binding|
|segmentation|
|regulation of Notch signaling pathway|
|female sex differentiation|
|B cell differentiation|
|protein O-linked glycosylation|
|lymphocyte activation involved in immune response|
|regulation of embryonic development|
|T cell differentiation|
|B cell activation|
|regulation of reproductive process|
|positive regulation of binding|
|gonad development|
|anterior/posterior pattern specification|
|development of primary sexual characteristics|
|regulation of protein binding|
|T cell activation|
|lymphocyte differentiation|
|protein glycosylation|
|macromolecule glycosylation|
|sex differentiation|
|glycosylation|
|glycoprotein biosynthetic process|
|leukocyte differentiation|
|regionalization|
|positive regulation of cell cycle|
|regulation of binding|
|lymphocyte activation|
|glycoprotein metabolic process|
|reproductive structure development|
|reproductive system development|
|pattern specification process|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|developmental process involved in reproduction|
|molecular function|
|anatomical structure formation involved in morphogenesis|
|leukocyte activation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|carbohydrate derivative metabolic process|
|regulation of anatomical structure morphogenesis|
|cell activation|
|immune effector process|
|epithelium development|
|regulation of cell cycle|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|cellular macromolecule biosynthetic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.82|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.82|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.05|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.11|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|2.43|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.65|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|3.42|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LFNG Expression in NALM6 Cells: 4.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>