LGALS3 [The Human Chemical-Genetic Interaction Map Project]

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======= LGALS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGALS3
  * **<color #00a2e8>Official Name</color>**: galectin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3958|3958]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17931|P17931]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGALS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGALS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/153619|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. {ECO:0000250, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:19594635, ECO:0000269|PubMed:19616076}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gal-bind lectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of immunological synapse formation|
|negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|negative regulation of protein tyrosine phosphatase activity|
|regulation of immunological synapse formation|
|IgE binding|
|positive regulation of dendritic cell differentiation|
|regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|
|regulation of protein tyrosine phosphatase activity|
|positive regulation of protein homodimerization activity|
|regulation of dendritic cell differentiation|
|macrophage chemotaxis|
|macrophage migration|
|negative regulation of T cell receptor signaling pathway|
|positive regulation of calcium ion import|
|eosinophil chemotaxis|
|regulation of protein homodimerization activity|
|eosinophil migration|
|laminin binding|
|positive regulation of mononuclear cell migration|
|negative regulation of antigen receptor-mediated signaling pathway|
|regulation of T cell apoptotic process|
|protein phosphatase inhibitor activity|
|immunological synapse|
|chemoattractant activity|
|regulation of calcium ion import|
|regulation of T cell receptor signaling pathway|
|monocyte chemotaxis|
|negative regulation of endocytosis|
|regulation of mononuclear cell migration|
|positive chemotaxis|
|mononuclear cell migration|
|regulation of lymphocyte apoptotic process|
|positive regulation of protein localization to plasma membrane|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|negative regulation of phosphoprotein phosphatase activity|
|ficolin-1-rich granule membrane|
|positive regulation of protein localization to cell periphery|
|regulation of antigen receptor-mediated signaling pathway|
|negative regulation of protein dephosphorylation|
|regulation of leukocyte apoptotic process|
|neutrophil chemotaxis|
|protein phosphatase binding|
|spliceosomal complex|
|granulocyte chemotaxis|
|neutrophil migration|
|positive regulation of protein binding|
|regulation of protein localization to plasma membrane|
|secretory granule membrane|
|granulocyte migration|
|negative regulation of extrinsic apoptotic signaling pathway|
|negative regulation of phosphatase activity|
|negative regulation of T cell activation|
|negative regulation of dephosphorylation|
|regulation of protein localization to cell periphery|
|regulation of phosphoprotein phosphatase activity|
|negative regulation of immune effector process|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of calcium ion transport|
|positive regulation of protein localization to membrane|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|regulation of protein dephosphorylation|
|negative regulation of lymphocyte activation|
|leukocyte chemotaxis|
|positive regulation of leukocyte differentiation|
|negative regulation of immune response|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of T cell proliferation|
|carbohydrate binding|
|negative regulation of cell-cell adhesion|
|negative regulation of leukocyte activation|
|regulation of phosphatase activity|
|positive regulation of binding|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|regulation of leukocyte migration|
|negative regulation of cell activation|
|regulation of endocytosis|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|cell chemotaxis|
|regulation of dephosphorylation|
|regulation of protein binding|
|regulation of leukocyte proliferation|
|negative regulation of apoptotic signaling pathway|
|regulation of myeloid cell differentiation|
|regulation of calcium ion transport|
|regulation of leukocyte differentiation|
|negative regulation of cell adhesion|
|positive regulation of ion transport|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of cellular protein localization|
|collagen-containing extracellular matrix|
|regulation of binding|
|leukocyte migration|
|regulation of metal ion transport|
|mitochondrial inner membrane|
|regulation of cell-cell adhesion|
|regulation of apoptotic signaling pathway|
|RNA splicing|
|negative regulation of immune system process|
|regulation of hemopoiesis|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|mRNA processing|
|negative regulation of transport|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of lymphocyte activation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|regulation of vesicle-mediated transport|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|myeloid leukocyte activation|
|negative regulation of protein modification process|
|regulation of leukocyte activation|
|cell surface|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|regulation of cell adhesion|
|epithelial cell differentiation|
|mRNA metabolic process|
|regulation of ion transport|
|regulated exocytosis|
|negative regulation of cellular component organization|
|leukocyte mediated immunity|
|innate immune response|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of cell migration|
|RNA processing|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|positive regulation of cell differentiation|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|secretion by cell|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|immune effector process|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|RNA metabolic process|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12765
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGALS3 Expression in NALM6 Cells: 1.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>