LGALS9B [The Human Chemical-Genetic Interaction Map Project]

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======= LGALS9B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LGALS9B
  * **<color #00a2e8>Official Name</color>**: galectin 9B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284194|284194]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3B8N2|Q3B8N2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LGALS9B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LGALS9B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Binds galactosides. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Gal-bind lectin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|galactoside binding|
|positive regulation of interleukin-10 secretion|
|negative regulation of CD4-positive, alpha-beta T cell proliferation|
|regulation of interleukin-10 secretion|
|negative regulation of alpha-beta T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell proliferation|
|negative regulation of CD4-positive, alpha-beta T cell activation|
|regulation of alpha-beta T cell proliferation|
|positive regulation of interleukin-6 secretion|
|negative regulation of interferon-gamma production|
|positive regulation of interleukin-10 production|
|negative regulation of alpha-beta T cell activation|
|regulation of interleukin-10 production|
|negative regulation of T cell proliferation|
|regulation of CD4-positive, alpha-beta T cell activation|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|regulation of alpha-beta T cell activation|
|positive regulation of interleukin-6 production|
|regulation of interferon-gamma production|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|negative regulation of lymphocyte activation|
|regulation of T cell proliferation|
|carbohydrate binding|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|negative regulation of cell activation|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of leukocyte proliferation|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|negative regulation of cytokine production|
|positive regulation of peptide secretion|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of immune system process|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of peptide secretion|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of secretion|
|positive regulation of transport|
|regulation of protein localization|
|negative regulation of multicellular organismal process|
|regulation of cell population proliferation|
|regulation of immune system process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of transport|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11169
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LGALS9B Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>