LHX2 [The Human Chemical-Genetic Interaction Map Project]

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======= LHX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: LHX2
  * **<color #00a2e8>Official Name</color>**: LIM homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9355|9355]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50458|P50458]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=LHX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20LHX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603759|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
|Homeobox|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maintenance of apical/basal cell polarity|
|maintenance of epithelial cell apical/basal polarity|
|telencephalon regionalization|
|maintenance of cell polarity|
|negative regulation of transcription regulatory region DNA binding|
|forebrain regionalization|
|olfactory bulb development|
|olfactory lobe development|
|axon extension|
|establishment or maintenance of epithelial cell apical/basal polarity|
|establishment or maintenance of bipolar cell polarity|
|establishment or maintenance of apical/basal cell polarity|
|regulation of transcription regulatory region DNA binding|
|positive regulation of neural precursor cell proliferation|
|negative regulation of DNA binding|
|neuron projection extension|
|hair follicle development|
|skin epidermis development|
|molting cycle process|
|hair cycle process|
|dorsal/ventral pattern formation|
|negative regulation of gene expression, epigenetic|
|regulation of neural precursor cell proliferation|
|developmental cell growth|
|cell growth|
|neural tube closure|
|tube closure|
|hair cycle|
|molting cycle|
|primary neural tube formation|
|neural tube formation|
|developmental growth involved in morphogenesis|
|cerebral cortex development|
|embryonic epithelial tube formation|
|mesoderm development|
|regulation of DNA binding|
|epithelial tube formation|
|retina development in camera-type eye|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|negative regulation of binding|
|pallium development|
|establishment or maintenance of cell polarity|
|regulation of gene expression, epigenetic|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|negative regulation of neurogenesis|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|camera-type eye development|
|regionalization|
|transcription factor binding|
|negative regulation of cell development|
|eye development|
|visual system development|
|sensory system development|
|axonogenesis|
|regulation of binding|
|skin development|
|forebrain development|
|developmental growth|
|growth|
|chromatin binding|
|axon development|
|epidermis development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|cell part morphogenesis|
|sensory organ development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|neuron projection development|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|locomotion|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of cell population proliferation|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13474
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='LHX2 Expression in NALM6 Cells: -1.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>